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    NBL1 borealin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 2746858, updated on 2-Nov-2024

    Summary

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    Official Symbol
    NBL1
    Official Full Name
    borealin
    Primary source
    SGD:S000029704
    Locus tag
    YHR199C-A
    See related
    AllianceGenome:SGD:S000029704; FungiDB:YHR199C-A; VEuPathDB:YHR199C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in chromosome segregation. Part of chromosome passenger complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See NBL1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    2
    Sequence:
    Chromosome: VIII; NC_001140.6 (498571..498859, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Aim18p Neighboring gene Aim46p Neighboring gene proteasome regulatory particle base subunit RPN10 Neighboring gene exopolyphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic interactions between specific chromosome copy number alterations dictate complex aneuploidy patterns. Ravichandran MC, et al. Genes Dev, 2018 Dec 1. PMID 30463904, Free PMC Article
    2. Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly. Ibarlucea-Benitez I, et al. J Cell Biol, 2018 May 7. PMID 29563217, Free PMC Article
    3. Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation. Zimniak T, et al. Curr Biol, 2012 May 8. PMID 22521784
    4. Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Nakajima Y, et al. Mol Biol Cell, 2009 Mar. PMID 19158380, Free PMC Article
    5. Tension sensing by Aurora B kinase is independent of survivin-based centromere localization. Campbell CS, et al. Nature, 2013 May 2. PMID 23604256, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nbl1p colocalizes and copurifies with the chromosomal passenger complex
      Title: Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of chromosome passenger complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    borealin
    NP_976247.1
    • Subunit of the conserved chromosomal passenger complex (CPC); complex regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p; other complex members are Ipl1p, Sli15p, and Bir1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      498571..498859 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184671.1 → NP_976247.1  TPA: borealin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_976247.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLE8, Q3E7Y6
      UniProtKB/TrEMBL
      A6ZTA6, B3LSW0, C8ZA00, G2WFS3, N1P2J8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E7Y6.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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