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    KGD1 alpha-ketoglutarate dehydrogenase KGD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854681, updated on 2-Nov-2024

    Summary

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    Official Symbol
    KGD1
    Official Full Name
    alpha-ketoglutarate dehydrogenase KGD1
    Primary source
    SGD:S000001387
    Locus tag
    YIL125W
    See related
    AllianceGenome:SGD:S000001387; FungiDB:YIL125W; VEuPathDB:YIL125W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OGD1
    Summary
    Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Predicted to be involved in tricarboxylic acid cycle. Located in mitochondrial nucleoid. Part of oxoglutarate dehydrogenase complex. Is active in mitochondrion. Human ortholog(s) of this gene implicated in Yoon-Bellen neurodevelopmental syndrome and oxoglutarate dehydrogenase deficiency. Orthologous to several human genes including OGDH (oxoglutarate dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See KGD1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (122689..125733)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Rrt14p Neighboring gene RSC chromatin remodeling complex ATPase subunit STH1 Neighboring gene acylglycerone-phosphate reductase Neighboring gene putative glucosidase SIM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The OGD1 gene, affecting 2-oxoglutarate dehydrogenase in S. cerevisiae, is closely linked to HIS5 on chromosome IX. Ruttkay-Nedecký B, et al. Curr Genet, 1990 Jan. PMID 2178788
    2. The properties of the multicopy suppressor of the ogd1 mutation in yeast. Gbelská Y, et al. J Basic Microbiol, 1995. PMID 7473064
    3. The ogd1 and kgd1 mutants lacking 2-oxoglutarate dehydrogenase activity in yeast are allelic and can be differentiated by the cloned amber suppressor. Mockovciaková D, et al. Curr Genet, 1993 Nov. PMID 8299151
    4. Elucidation of ethanol tolerance mechanisms in Saccharomyces cerevisiae by global metabolite profiling. Kim S, et al. Biotechnol J, 2016 Sep. PMID 27313052
    5. Alpha-Ketoglutarate dehydrogenase and lipoic acid synthase are important for the functioning of peroxisomes of Saccharomyces cerevisiae. Smaczyńska-de Rooij I, et al. Cell Mol Biol Lett, 2004. PMID 15213808

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxoglutarate dehydrogenase (succinyl-transferring) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables thiamine pyrophosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular respiration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial nucleoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of oxoglutarate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-ketoglutarate dehydrogenase KGD1
    NP_012141.1
    • Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex; catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      122689..125733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179473.1 → NP_012141.1  TPA: alpha-ketoglutarate dehydrogenase KGD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012141.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVG2, P20967
      UniProtKB/TrEMBL
      A6ZVF1, B3LTX2, C7GWJ5, C8ZAY8
      Conserved Domains (1) summary
      TIGR00239
      Location:44 → 1011
      2oxo_dh_E1; 2-oxoglutarate dehydrogenase, E1 component
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20967.2

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