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    MCO6 Mco6p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466466, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MCO6
    Official Full Name
    Mco6p
    Primary source
    SGD:S000028522
    Locus tag
    YJL127C-B
    See related
    AllianceGenome:SGD:S000028522; FungiDB:YJL127C-B; VEuPathDB:YJL127C-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YJL127C-A
    Summary
    Involved in mitochondrial outer membrane translocase complex assembly. Located in mitochondrial outer membrane. Part of SAM complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MCO6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (181551..181709, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Trk1p Neighboring gene mitogen-activated protein kinase kinase PBS2 Neighboring gene Spt10p Neighboring gene putative hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of the small protein Mco6 in the mitochondrial sorting and assembly machinery. Busto JV, et al. Cell Rep, 2024 Mar 26. PMID 38377000
    2. Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. Brachat S, et al. Genome Biol, 2003. PMID 12844361, Free PMC Article
    3. Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale. Morgenstern M, et al. Cell Rep, 2017 Jun 27. PMID 28658629, Free PMC Article
    4. Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. Galibert F, et al. EMBO J, 1996 May 1. PMID 8641269, Free PMC Article
    5. Association of yeast Upf1p with direct substrates of the NMD pathway. Johansson MJ, et al. Proc Natl Acad Sci U S A, 2007 Dec 26. PMID 18087042, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial outer membrane translocase complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial outer membrane translocase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in outer mitochondrial membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mco6p
    NP_878103.1
    • Mitochondrial outer membrane protein protein; co-assembles with Mdm10p into the mitochondrial sorting and assembly machinery (SAM) complex and cooperates with Mdm10p in the assembly of the translocase of the outer membrane (TOM) complex; identified based on homology to the filamentous fungus, Ashbya gossypii; SWAT-GFP and seamless-GFP fusion proteins localize to the mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      181551..181709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184532.1 → NP_878103.1  TPA: Mco6p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878103.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW58, Q3E828
      UniProtKB/TrEMBL
      A6ZQK3, B3LPZ1, C7GQ01, C8ZB91, G2WGP5
      Conserved Domains (1) summary
      pfam17237
      Location:5 → 48
      DUF5310; Family of unknown function (DUF5310)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E828.1

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