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    IML2 Iml2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853363, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IML2
    Official Full Name
    Iml2p
    Primary source
    SGD:S000003618
    Locus tag
    YJL082W
    See related
    AllianceGenome:SGD:S000003618; FungiDB:YJL082W; VEuPathDB:YJL082W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cellular response to misfolded protein. Located in mitochondrial outer membrane and nucleus. Orthologous to several human genes including TTC39B (tetratricopeptide repeat domain 39B). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See IML2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (281185..283380)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Aly2p Neighboring gene Tax4p Neighboring gene Arp4p Neighboring gene Scp160p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies. Moldavski O, et al. Dev Cell, 2015 Jun 8. PMID 26004510
    2. Heterozygous mutations cause genetic instability in a yeast model of cancer evolution. Coelho MC, et al. Nature, 2019 Feb. PMID 30700905, Free PMC Article
    3. Interactomic study on interaction between lipid droplets and mitochondria. Pu J, et al. Protein Cell, 2011 Jun. PMID 21748599, Free PMC Article
    4. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article
    5. The RNA-binding protein Puf5 contributes to buffering of mRNA upon chromatin-mediated changes in nascent transcription. Kochan DZ, et al. J Cell Sci, 2021 Aug 1. PMID 34350963, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to misfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Iml2p
    NP_012453.1
    • Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      281185..283380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181515.1 → NP_012453.1  TPA: Iml2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012453.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZPP2, D6VWA1, P47031
      UniProtKB/TrEMBL
      B3LQ30, B5VL95, C7GR31, D3UF60, G2WGT5, N1P8G1
      Conserved Domains (1) summary
      pfam10300
      Location:38 → 622
      DUF3808; Protein of unknown function (DUF3808)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47031.1

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