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    PET191 Pet191p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853491, updated on 29-Jun-2024

    Summary

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    Gene symbol
    PET191
    Gene description
    Pet191p
    Primary source
    FungiDB:YJR034W
    Locus tag
    YJR034W
    See related
    SGD:S000003795; AllianceGenome:SGD:S000003795; VEuPathDB:YJR034W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrial intermembrane space. Is integral component of mitochondrial inner membrane. Human ortholog(s) of this gene implicated in fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 3. Orthologous to human COA5 (cytochrome c oxidase assembly factor 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PET191 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (496683..497009)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase CPR7 Neighboring gene Rav1p Neighboring gene DNA-dependent ATPase RAD26 Neighboring gene putative E3 ubiquitin-protein ligase HUL4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pet191 is a cytochrome c oxidase assembly factor in Saccharomyces cerevisiae. Khalimonchuk O, et al. Eukaryot Cell, 2008 Aug. PMID 18503002, Free PMC Article
    2. Flux balance analysis of a genome-scale yeast model constrained by exometabolomic data allows metabolic system identification of genetically different strains. Cakir T, et al. Biotechnol Prog, 2007 Mar-Apr. PMID 17373823
    3. Optimization of ethanol production from starch by an amylolytic nuclear petite Saccharomyces cerevisiae strain. Toksoy Oner E. Yeast, 2006 Sep. PMID 17001624
    4. Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiae. McEwen JE, et al. Curr Genet, 1993 Jan. PMID 8381337
    5. Quantitative analysis of yeast gene function using competition experiments in continuous culture. Baganz F, et al. Yeast, 1998 Nov. PMID 9848233

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pet191p
    NP_012568.1
    • Protein required for assembly of cytochrome c oxidase; exists as an oligomer; described as both an integral mitochondrial inner membrane protein facing the intermembrane space (IMS) and as a soluble IMS protein; contains a twin Cx9C motif; imported into the IMS via the MIA import machinery

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      496683..497009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181692.1 → NP_012568.1  TPA: Pet191p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012568.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWK7, Q02772
      UniProtKB/TrEMBL
      A0A6A5PWW8, A6ZPZ5, B3LQC5, C7GKY6, C8ZBI5, G2WH40, N1P1I7
      Conserved Domains (1) summary
      pfam10203
      Location:4 → 70
      Pet191_N; Cytochrome c oxidase assembly protein PET191
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02772.1

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