GPT2 bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: GPT2
Gene description: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2
Primary source: FungiDB:YKR067W
Locus tag: YKR067W
See related: SGD:S000001775; AllianceGenome:SGD:S000001775; VEuPathDB:YKR067W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAT1
Summary: Enables glycerol-3-phosphate O-acyltransferase activity and glycerone-phosphate O-acyltransferase activity. Involved in phospholipid biosynthetic process and regulation of triglyceride metabolic process. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GPT2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (567918..570149)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the model organism yeast the lipid droplet associated GPAT Gpt2 requires phosphorylation at a conserved motif to prevent a futile triacylglycerol cycle.
Title: Phosphorylation of the lipid droplet localized glycerol‑3‑phosphate acyltransferase Gpt2 prevents a futile triacylglycerol cycle in yeast.
results argue that motifs I, II and III of Gpt2p are in the lumen of the endoplasmic reticulum (ER) and support the notion that the active site of Gpt2p resides in the ER lumen
Title: Topology of the microsomal glycerol-3-phosphate acyltransferase Gpt2p/Gat1p of Saccharomyces cerevisiae.
Gat1 and Gat2 localized to both perinuclear and cortical endoplasmic reticula in actively proliferating cells.
Title: Glycerol-3-phosphate acyltransferases gat1p and gat2p are microsomal phosphoproteins with differential contributions to polarized cell growth.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerone-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerone-phosphate O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerone-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2

NP_012993.3

EC 2.3.1.15

EC 2.3.1.42

Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase; located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis; the most conserved motifs and functionally relevant residues are oriented towards the ER lumen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

567918..570149

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179857.3 → NP_012993.3 TPA: bifunctional glycerol-3-phosphate/glycerone-phosphate O-acyltransferase GPT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012993.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXC8, P36148

UniProtKB/TrEMBL

A0A8H4F8X1, A7A027, B3LRE2, C8ZCM9, N1P2R7

Conserved Domains (1) summary

cl17185
Location:45 → 348

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis