FPS1 Fps1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: FPS1
Gene description: Fps1p
Primary source: FungiDB:YLL043W
Locus tag: YLL043W
See related: SGD:S000003966; AllianceGenome:SGD:S000003966; VEuPathDB:YLL043W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycerol channel activity. Involved in anion transport; conjugation with cellular fusion; and glycerol transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in kidney disease. Orthologous to human AQP9 (aquaporin 9). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See FPS1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (49938..51947)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of the glycerol transporter channel Fps1p in cellular proteostasis during enhanced proteotoxic stress.
Title: The role of the glycerol transporter channel Fps1p in cellular proteostasis during enhanced proteotoxic stress.
Report shows that Slt2 is phosphorylated following arsenite treatment. Slt2 and its kinase activity are necessary for full acquisition of arsenite tolerance and this effect appears to be mediated through Fps1. Hence, it appears that two MAPKs, Hog1 and Slt2, collaborate in controlling arsenite influx and efflux through Fps1 suggesting a mechanism where this MAPK collaboration may function on Fps1.
Title: The mitogen-activated protein kinase Slt2 modulates arsenite transport through the aquaglyceroporin Fps1.
Moreover, hyperosmotic conditions block TORC2-dependent Ypk1-mediated Fps1 phosphorylation, causing channel closure, glycerol accumulation, and enhanced survival under hyperosmotic stress.
Title: Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress.
results show the function of Stl1p and Fps1p transporters contributes to cell's ability to survive during transfer into state of anhydrobiosis; deletion of FPS1 decreases cell's tolerance of hyperosmotic stress; deletion of STL1 results in slight increase in cell size and increase in intracellular pH
Title: The role of glycerol transporters in yeast cells in various physiological and stress conditions.
Fps1 is key for downstream signaling in the Sho1-mediated branch of the high-osmolarity glycerol mitogen-activated protein kinase pathway pathway.
Title: A Comprehensive Membrane Interactome Mapping of Sho1p Reveals Fps1p as a Novel Key Player in the Regulation of the HOG Pathway in S. cerevisiae.
Activation of Hog1 in response to hyperosmotic shock induces the rapid eviction of Rgc2 from Fps1 and consequent channel closure
Title: MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.
Data suggest a mechanism for regulation of glycerol flux in yeast, where the termini alone are not sufficient to restrict Fps1 transport.
Title: Yeast aquaglyceroporins use the transmembrane core to restrict glycerol transport.
Fps1 functions as a homotetramer to regulate glycerol transport in yeast.
Title: Yeast Fps1 glycerol facilitator functions as a homotetramer.
Data show that Fps1p in concert with the arsenite transporter Acr3p mediates arsenite efflux.
Title: The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel.
Hog1 was also required for basal phosphorylation of ASK10, suggesting a mechanism by which Hog1 may regulate Fps1 indirectly
Title: Identification of positive regulators of the yeast fps1 glycerol channel.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glycerol transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acetate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in arsenite transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polyol transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in polyol transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Fps1p

NP_013057.1

Aquaglyceroporin, plasma membrane channel; involved in efflux of glycerol and xylitol, and in transport of acetate, arsenite, and antimonite; key factor in maintaining redox balance by mediating passive diffusion of glycerol; phosphorylated by Hog1p and Slt2p MAPK; deletion improves xylose fermentation; regulated by Rgc1p and Ask10p, which are regulated by Hog1p phosphorylation under osmotic stress; phosphorylation by Ypk1p required to maintain an open state