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    FRA1 aminopeptidase P [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850630, updated on 3-Nov-2024

    Summary

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    Official Symbol
    FRA1
    Official Full Name
    aminopeptidase P
    Primary source
    SGD:S000003952
    Locus tag
    YLL029W
    See related
    AllianceGenome:SGD:S000003952; FungiDB:YLL029W; VEuPathDB:YLL029W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable metal ion binding activity and metalloaminopeptidase activity. Involved in cellular response to iron ion and negative regulation of transcription by RNA polymerase II. Located in cytosol. Human ortholog(s) of this gene implicated in acquired angioedema. Orthologous to several human genes including XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See FRA1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (81461..83710)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mannose-ethanolamine phosphotransferase GPI13 Neighboring gene Rrt7p Neighboring gene polyamine transporter TPO1 Neighboring gene Fe-binding Fe/S cluster assembly protein ISA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial Cochaperone Mge1 Is Involved in Regulating Susceptibility to Fluconazole in Saccharomyces cerevisiae and Candida Species. Demuyser L, et al. mBio, 2017 Jul 18. PMID 28720726, Free PMC Article
    2. Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae. Briza P, et al. Yeast, 2002 Mar 30. PMID 11921089
    3. The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation. Li H, et al. Biochemistry, 2009 Oct 13. PMID 19715344, Free PMC Article
    4. Loss of vacuolar H+-ATPase (V-ATPase) activity in yeast generates an iron deprivation signal that is moderated by induction of the peroxiredoxin TSA2. Diab HI, et al. J Biol Chem, 2013 Apr 19. PMID 23457300, Free PMC Article
    5. Disruption of six novel ORFs on the left arm of chromosome XII reveals one gene essential for vegetative growth of Saccharomyces cerevisiae. Zhang N, et al. Yeast, 1999 Sep 15. PMID 10487931

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to iron ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to iron ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    aminopeptidase P
    NP_013071.1
    • Protein involved in negative regulation of iron regulon transcription; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      81461..83710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181849.1 → NP_013071.1  TPA: aminopeptidase P [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013071.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXX5, Q07825
      UniProtKB/TrEMBL
      A7A0M8, N1NYH5
      Conserved Domains (4) summary
      cd01085
      Location:463 → 688
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam16188
      Location:687 → 749
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:282 → 460
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain
      cl23800
      Location:109 → 270
      Creatinase_N; Creatinase/Prolidase N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07825.1

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