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    BNA5 kynureninase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850933, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BNA5
    Official Full Name
    kynureninase
    Primary source
    SGD:S000004221
    Locus tag
    YLR231C
    See related
    AllianceGenome:SGD:S000004221; FungiDB:YLR231C; VEuPathDB:YLR231C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables kynureninase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hydroxykynureninuria. Orthologous to human KYNU (kynureninase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BNA5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (605758..607119, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rho family GTPase CDC42 Neighboring gene tRNA-Ile Neighboring gene Est1p Neighboring gene DNA topoisomerase 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Independent regulation of age associated fat accumulation and longevity. Beas AO, et al. Nat Commun, 2020 Jun 3. PMID 32493904, Free PMC Article
    2. Aerobic and anaerobic NAD+ metabolism in Saccharomyces cerevisiae. Panozzo C, et al. FEBS Lett, 2002 Apr 24. PMID 12062417
    3. NAD+-dependent deacetylase Hst1p controls biosynthesis and cellular NAD+ levels in Saccharomyces cerevisiae. Bedalov A, et al. Mol Cell Biol, 2003 Oct. PMID 12972620, Free PMC Article
    4. A quantitative screen for metabolic enzyme structures reveals patterns of assembly across the yeast metabolic network. Noree C, et al. Mol Biol Cell, 2019 Oct 1. PMID 31483745, Free PMC Article
    5. Tryptophan plays an important role in yeast's tolerance to isobutanol. Liu HL, et al. Biotechnol Biofuels, 2021 Oct 13. PMID 34645498, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynureninase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kynureninase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kynureninase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' NAD biosynthetic process from tryptophan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in L-kynurenine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anthranilate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anthranilate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in quinolinate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kynureninase
    NP_013332.1
    • Kynureninase; required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      605758..607119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182118.1 → NP_013332.1  TPA: kynureninase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013332.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYN2, Q05979
      UniProtKB/TrEMBL
      A7A1B7, B3RHB9, B5VNE7, C7GR02, C8ZDJ5, G2WJ59, N1NYF6
      Conserved Domains (1) summary
      TIGR01814
      Location:4 → 451
      kynureninase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05979.1

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