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    TUS1 Rho family guanine nucleotide exchange factor TUS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851145, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TUS1
    Official Full Name
    Rho family guanine nucleotide exchange factor TUS1
    Primary source
    SGD:S000004417
    Locus tag
    YLR425W
    See related
    AllianceGenome:SGD:S000004417; FungiDB:YLR425W; VEuPathDB:YLR425W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SOP10
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in fungal-type cell wall organization; positive regulation of mitotic actomyosin contractile ring assembly; and signal transduction. Located in cellular bud neck and incipient cellular bud site. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See TUS1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (982894..986817)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SPP382 Neighboring gene tRNA-Asn Neighboring gene Tda5p Neighboring gene Mag2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A comparative analysis of NADPH supply strategies in Saccharomyces cerevisiae: Production of d-xylitol from d-xylose as a case study. Regmi P, et al. Metab Eng Commun, 2024 Dec. PMID 39072283, Free PMC Article
    2. Yeast Cell Wall Chitin Reduces Wine Haze Formation. Ndlovu T, et al. Appl Environ Microbiol, 2018 Jul 1. PMID 29703738, Free PMC Article
    3. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Yoshida S, et al. Science, 2006 Jul 7. PMID 16763112
    4. Sro7 and Sro77, the yeast homologues of the Drosophila lethal giant larvae (Lgl), regulate cell proliferation via the Rho1-Tor1 pathway. Liou LC, et al. Microbiology (Reading), 2014 Oct. PMID 25061043, Free PMC Article
    5. G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae. Kono K, et al. Mol Biol Cell, 2008 Apr. PMID 18256282, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. propose that Cln2p/Cdc28p-dependent phosphorylation of Tus1p is required for appropriate temporal and spatial activation of Rho1p at the G1/S transition
      Title: G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae.
    2. Transport assays show that Tus1p, a guanine nucleotide exchange factor (GEF) for the small GTPase Rho1p, is a Rho1p-dependent-positive regulator of Ycf1p.
      Title: Mapping protein-protein interactions for the yeast ABC transporter Ycf1p by integrated split-ubiquitin membrane yeast two-hybrid analysis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitotic actomyosin contractile ring assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of mitotic actomyosin contractile ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell wall organization or biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell periphery IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho family guanine nucleotide exchange factor TUS1
    NP_013529.3
    • Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity; involved in the cell integrity signaling pathway; interacts with Rgl1p; localization of Tus1p to the bed neck is regulated by Rgl1p; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      982894..986817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182313.3 → NP_013529.3  TPA: Rho family guanine nucleotide exchange factor TUS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013529.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ61, Q06412
      UniProtKB/TrEMBL
      C7GSM8
      Conserved Domains (2) summary
      smart00036
      Location:939 → 1287
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd00160
      Location:469 → 655
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06412.1

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