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    INP2 Inp2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855198, updated on 29-Jun-2024

    Summary

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    Gene symbol
    INP2
    Gene description
    Inp2p
    Primary source
    FungiDB:YMR163C
    Locus tag
    YMR163C
    See related
    SGD:S000004773; AllianceGenome:SGD:S000004773; VEuPathDB:YMR163C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-membrane adaptor activity. Involved in peroxisome inheritance. Is integral component of peroxisomal membrane. Colocalizes with peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See INP2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (584271..586388, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene type I HSP40 co-chaperone HLJ1 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF3 Neighboring gene tRNA-Val Neighboring gene Mss11p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin-driven peroxisome partitioning in S. cerevisiae. Fagarasanu A, et al. J Cell Biol, 2009 Aug 24. PMID 19687257, Free PMC Article
    2. Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. Choudhry SK, et al. J Cell Sci, 2018 Feb 7. PMID 29361529
    3. Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p. Otzen M, et al. Traffic, 2012 Jul. PMID 22486971
    4. The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae. Fagarasanu A, et al. Dev Cell, 2006 May. PMID 16678774
    5. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. Tang K, et al. J Biol Chem, 2019 Apr 12. PMID 30804213, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inp2p together with Pex19p is required for proper association of peroxisomes to Myo2p.
      Title: Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.
    2. Inp2p is the first peroxisomal protein implicated in the vectorial movement of peroxisomes.Inp2p interacts directly with the globular tail of Myo2p.
      Title: The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome inheritance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in peroxisome inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome inheritance IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Inp2p
    NP_013886.1
    • Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      584271..586388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182667.1 → NP_013886.1  TPA: Inp2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013886.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZY5, Q03824
      UniProtKB/TrEMBL
      A0A8H4F9J1, C8ZF23, G2WKL6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03824.1

    Gene LinkOut

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