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    MSS11 Mss11p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855200, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSS11
    Official Full Name
    Mss11p
    Primary source
    SGD:S000004774
    Locus tag
    YMR164C
    See related
    AllianceGenome:SGD:S000004774; FungiDB:YMR164C; VEuPathDB:YMR164C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of flocculation; positive regulation of growth of unicellular organism as a thread of attached cells; and positive regulation of macromolecule metabolic process. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MSS11 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (587274..589550, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Inp2p Neighboring gene tRNA-Val Neighboring gene phosphatidate phosphatase PAH1 Neighboring gene Mme1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mss11p is a transcription factor regulating pseudohyphal differentiation, invasive growth and starch metabolism in Saccharomyces cerevisiae in response to nutrient availability. Gagiano M, et al. Mol Microbiol, 2003 Jan. PMID 12492858
    2. STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae. Kim TS, et al. Curr Genet, 2003 Dec. PMID 14523573
    3. MSS11, a novel yeast gene involved in the regulation of starch metabolism. Webber AL, et al. Curr Genet, 1997 Oct. PMID 9342405
    4. Mss11, a transcriptional activator, is required for hyphal development in Candida albicans. Su C, et al. Eukaryot Cell, 2009 Nov. PMID 19734367, Free PMC Article
    5. Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae. Gagiano M, et al. Mol Microbiol, 1999 Jan. PMID 9987114

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. While alleles of the transcription factor MSS11 specify the potential temperatures at which the trait can occur, alleles at the other loci modify temperature sensitivity within the range established by MSS11 in a genetic background
      Title: Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait.
    2. Flo8 and Mss11 can directly form either a heterodimer or a homodimer capable of binding to DNA, and this formed complex of two activators interacts functionally and physically with the Swi/Snf complex.
      Title: Two distinct domains of Flo8 activator mediates its role in transcriptional activation and the physical interaction with Mss11.
    3. Mss11p, together with Flo8p, induces flocculation in Saccharomyces cerevisiae
      Title: The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p.
    4. Flo8 interacts physically and functionally with Mss11
      Title: Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of flocculation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of invasive growth in response to glucose limitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of pseudohyphal growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of starch catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of primary metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mss11p
    NP_013887.1
    • Transcription factor; involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals; forms a heterodimer with Flo8p that interacts with the Swi/Snf complex during transcriptional activation of FLO1, FLO11, and STA1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      587274..589550 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182668.1 → NP_013887.1  TPA: Mss11p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013887.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZY6, Q03825
      UniProtKB/TrEMBL
      C7GU58, N1P0F0
      Conserved Domains (1) summary
      pfam08513
      Location:54 → 78
      LisH
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03825.1

    Gene LinkOut

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