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    ISU2 putative iron-binding protein ISU2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854401, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ISU2
    Official Full Name
    putative iron-binding protein ISU2
    Primary source
    SGD:S000005752
    Locus tag
    YOR226C
    See related
    AllianceGenome:SGD:S000005752; FungiDB:YOR226C; VEuPathDB:YOR226C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NUA2
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and ferrous iron binding activity. Involved in intracellular iron ion homeostasis; iron-sulfur cluster assembly; and tRNA wobble uridine modification. Located in mitochondrial matrix. Used to study mitochondrial myopathy. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ISU2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (761614..762084, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Dsc3p Neighboring gene DNA-directed RNA polymerase core subunit RPB8 Neighboring gene Her1p Neighboring gene Mcp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast scaffold proteins Isu1p and Isu2p are required inside mitochondria for maturation of cytosolic Fe/S proteins. Gerber J, et al. Mol Cell Biol, 2004 Jun. PMID 15143178, Free PMC Article
    2. Thio modification of yeast cytosolic tRNA is an iron-sulfur protein-dependent pathway. Nakai Y, et al. Mol Cell Biol, 2007 Apr. PMID 17283054, Free PMC Article
    3. Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae. Ramazzotti A, et al. FEBS Lett, 2004 Jan 16. PMID 14741370
    4. A novel de novo dominant mutation in ISCU associated with mitochondrial myopathy. Legati A, et al. J Med Genet, 2017 Dec. PMID 29079705, Free PMC Article
    5. Sequence-specific interaction between mitochondrial Fe-S scaffold protein Isu and Hsp70 Ssq1 is essential for their in vivo function. Dutkiewicz R, et al. J Biol Chem, 2004 Jul 9. PMID 15123690

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron-sulfur cluster assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA wobble uridine modification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative iron-binding protein ISU2
    NP_014869.3
    • Mitochondrial protein required for iron-sulfur protein synthesis; performs scaffolding function during Fe/S cluster assembly; involved in Fe-S cluster assembly for both mitochondrial and cytosolic proteins; protein abundance increases under DNA replication stress; ISU2 has a paralog, ISU1, that arose from the whole genome duplication; isu1 isu2 double mutant is inviable; human homolog ISCU implicated in mitochondrial myopathy, can complement isu1 isu2 double mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      761614..762084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183645.3 → NP_014869.3  TPA: putative iron-binding protein ISU2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014869.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2T0, Q12056
      UniProtKB/TrEMBL
      A6ZP67, B3LJP8, C7GWF8, C8ZGX9, G2WN96, N1P3H0
      Conserved Domains (1) summary
      TIGR01999
      Location:27 → 151
      iscU; FeS cluster assembly scaffold IscU
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12056.1

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