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    MKK1 mitogen-activated protein kinase kinase MKK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854406, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MKK1
    Official Full Name
    mitogen-activated protein kinase kinase MKK1
    Primary source
    SGD:S000005757
    Locus tag
    YOR231W
    See related
    AllianceGenome:SGD:S000005757; FungiDB:YOR231W; VEuPathDB:YOR231W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SSP32
    Summary
    Enables protein kinase activity. Involved in cell integrity MAPK cascade; pexophagy; and regulation of fungal-type cell wall organization. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Orthologous to human MAP2K5 (mitogen-activated protein kinase kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MKK1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (772601..774127)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene transcriptional modulator Neighboring gene transcriptional modulator Neighboring gene Mge1p Neighboring gene putative serine/threonine protein kinase KIN4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Yashar BM, et al. Mol Cell Biol, 1993 Sep. PMID 8395011, Free PMC Article
    2. A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway. Fairn GD, et al. J Biol Chem, 2007 Feb 16. PMID 17164236
    3. Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway. Jiménez-Sánchez M, et al. J Biol Chem, 2007 Oct 26. PMID 17711850
    4. Differential Role of Threonine and Tyrosine Phosphorylation in the Activation and Activity of the Yeast MAPK Slt2. González-Rubio G, et al. Int J Mol Sci, 2021 Jan 23. PMID 33498635, Free PMC Article
    5. Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases. Levin-Salomon V, et al. J Biol Chem, 2008 Dec 12. PMID 18829462, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. biochemical and genetic evidence that Mkk1 transmits most of the signaling through the CWI pathway and that Ptc1 directly downregulates the CWI pathway at the level of the MAPKKs
      Title: Wide-Ranging Effects of the Yeast Ptc1 Protein Phosphatase Acting Through the MAPK Kinase Mkk1.
    2. Retrophosphorylation of MKK1 by the SLT2 MAPK in the yeast cell integrity pathway is reported.
      Title: Retrophosphorylation of Mkk1 and Mkk2 MAPKKs by the Slt2 MAPK in the yeast cell integrity pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell integrity MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell integrity MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pexophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase MKK1
    NP_014874.1
    • MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      772601..774127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183650.1 → NP_014874.1  TPA: mitogen-activated protein kinase kinase MKK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2T5, P32490, Q2VQW6
      UniProtKB/TrEMBL
      A6ZP72, B3LJQ3, C8ZGY4, G2WNA1, N1P3H6
      Conserved Domains (1) summary
      cl21453
      Location:219 → 506
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32490.1

    Gene LinkOut

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