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    KIN4 putative serine/threonine protein kinase KIN4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854408, updated on 3-Nov-2024

    Summary

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    Official Symbol
    KIN4
    Official Full Name
    putative serine/threonine protein kinase KIN4
    Primary source
    SGD:S000005759
    Locus tag
    YOR233W
    See related
    AllianceGenome:SGD:S000005759; FungiDB:YOR233W; VEuPathDB:YOR233W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KIN3; KIN31
    Summary
    Enables protein serine/threonine kinase activity. Involved in mitotic spindle orientation checkpoint signaling and protein localization to spindle pole body. Acts upstream of or within peroxisome inheritance and vacuole inheritance. Located in cell cortex; cellular bud neck; and spindle pole body. Human ortholog(s) of this gene implicated in anencephaly and uterine fibroid. Orthologous to human NUAK1 (NUAK family kinase 1) and NUAK2 (NUAK family kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See KIN4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (775846..778248)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase MKK1 Neighboring gene Mge1p Neighboring gene ribosomal 60S subunit protein L33B Neighboring gene Irc13p Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and genetic analysis of the gene encoding a new protein kinase in Saccharomyces cerevisiae. Kambouris NG, et al. Yeast, 1993 Feb. PMID 8465601
    2. Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae. Boyer J, et al. Yeast, 1996 Dec. PMID 8972580
    3. Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4. Falk JE, et al. Proc Natl Acad Sci U S A, 2011 Aug 2. PMID 21709215, Free PMC Article
    4. Elm1 kinase activates the spindle position checkpoint kinase Kin4. Caydasi AK, et al. J Cell Biol, 2010 Sep 20. PMID 20855503, Free PMC Article
    5. The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes. Caydasi AK, et al. Mol Biol Cell, 2014 Jul 15. PMID 24850890, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae.
      Title: Spindle Position Checkpoint Kinase Kin4 Regulates Organelle Transport in Saccharomyces cerevisiae.
    2. Data show that bud-localized MEN regulator Lte1 prevents Kin4 that escapes into the bud from associating with SPBs in the daughter cell.
      Title: Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4.
    3. Data suggest that Lte1 promotes mitotic exit by inhibiting Kin4 activity at the daughter spindle pole body.
      Title: The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4.
    4. The bud neck-associated kinase Elm1 participates in Kin4 activation and SPOC signaling by phosphorylating a conserved residue within the activation loop of Kin4.
      Title: Elm1 kinase activates the spindle position checkpoint kinase Kin4.
    5. show that the protein phosphatase functions upstream of Kin4, regulating the kinase's phosphorylation and localization during an unperturbed cell cycle and during SPOC activation, thus defining the phosphatase as a key regulator of SPOC function
      Title: The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle orientation checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome inheritance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to spindle pole body IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vacuole inheritance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase KIN4
    NP_014876.1
    • Serine/threonine protein kinase; inhibits the mitotic exit network (MEN) when the spindle position checkpoint (SPOC) is activated; regulates peroxisomal transport and vacuolar inheritance along with Frk1p; protects the peroxisomal Myo2p receptor Inp2p from degradation in mother cells along with Frk1p; localizes asymmetrically to mother cell cortex, spindle pole body and bud neck; KIN4 has a paralog, FRK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      775846..778248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183652.1 → NP_014876.1  TPA: putative serine/threonine protein kinase KIN4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014876.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2T7, Q01919
      UniProtKB/TrEMBL
      A6ZP74, B3LJQ5, B5VSB4, C7GWF1, C8ZGY7, N1NWU2
      Conserved Domains (1) summary
      cd14076
      Location:44 → 313
      STKc_Kin4; Catalytic domain of the yeast Serine/Threonine Kinase, Kin4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01919.1

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