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    HES1 oxysterol-binding protein related protein HES1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854412, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HES1
    Official Full Name
    oxysterol-binding protein related protein HES1
    Primary source
    SGD:S000005763
    Locus tag
    YOR237W
    See related
    AllianceGenome:SGD:S000005763; FungiDB:YOR237W; VEuPathDB:YOR237W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    OSH5
    Summary
    Enables oxysterol binding activity and sterol transfer activity. Involved in several processes, including maintenance of cell polarity; piecemeal microautophagy of the nucleus; and sterol transport. Located in cellular bud neck and fungal-type vacuole membrane. Orthologous to several human genes including OSBPL11 (oxysterol binding protein like 11). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HES1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (781994..783298)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Irc13p Neighboring gene ncRNA Neighboring gene dihydrofolate reductase Neighboring gene uncharacterized protein Neighboring gene tRNA(Thr) (cytosine(32)-N(3))-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sterol binding assay using surface plasmon fluorescence spectroscopy. Wiltschi B, et al. Anal Chem, 2006 Jan 15. PMID 16408938
    2. Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy. Muramoto M, et al. Biochim Biophys Acta Biomembr, 2024 Apr. PMID 38437942
    3. A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein. Jiang B, et al. Yeast, 1994 Mar. PMID 8017104
    4. Osh6 overexpression extends the lifespan of yeast by increasing vacuole fusion. Gebre S, et al. Cell Cycle, 2012 Jun 1. PMID 22622083
    5. Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast. Tian S, et al. J Biol Chem, 2018 Apr 13. PMID 29487131, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy.
      Title: Coordinated regulation of phosphatidylinositol 4-phosphate and phosphatidylserine levels by Osh4p and Osh5p is an essential regulatory mechanism in autophagy.
    2. Osh5-Osh7 bind cholesterol in vitro.
      Title: Oxysterol-binding protein homologs mediate sterol transport from the endoplasmic reticulum to mitochondria in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxysterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxysterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxysterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables sterol transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in maintenance of cell polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in piecemeal microautophagy of the nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sterol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein related protein HES1
    NP_014880.3
    • Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      781994..783298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183656.3 → NP_014880.3  TPA: oxysterol-binding protein related protein HES1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014880.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2U0, P35843
      UniProtKB/TrEMBL
      B3LJQ8, C7GWE9, N1NX89
      Conserved Domains (1) summary
      pfam01237
      Location:12 → 365
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35843.1

    Gene LinkOut

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