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    ALG5 dolichyl-phosphate beta-glucosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855874, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ALG5
    Official Full Name
    dolichyl-phosphate beta-glucosyltransferase
    Primary source
    SGD:S000006148
    Locus tag
    YPL227C
    See related
    AllianceGenome:SGD:S000006148; FungiDB:YPL227C; VEuPathDB:YPL227C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dolichyl-phosphate beta-glucosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Located in endoplasmic reticulum membrane. Used to study congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in polycystic kidney disease 7. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ALG5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (120163..121167, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene polynucleotide 5'-phosphatase Neighboring gene New1p Neighboring gene ribosome-associated Tef1p biogenesis chaperone CHP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation of the ALG5 locus encoding the UDP-glucose:dolichyl-phosphate glucosyltransferase from Saccharomyces cerevisiae. Heesen S, et al. Eur J Biochem, 1994 Aug 15. PMID 8076653
    2. Evidence that the synthesis of glucosylphosphodolichol in yeast involves a 35-kDa membrane protein. Palamarczyk G, et al. Proc Natl Acad Sci U S A, 1990 Apr. PMID 2138781, Free PMC Article
    3. Two yeast mutations in glucosylation steps of the asparagine glycosylation pathway. Runge KW, et al. J Biol Chem, 1984 Jan 10. PMID 6423630
    4. A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo. Stagljar I, et al. Proc Natl Acad Sci U S A, 1998 Apr 28. PMID 9560251, Free PMC Article
    5. A hypomorphic allele of the first N-glycosylation gene, ALG7, causes mitochondrial defects in yeast. Mendelsohn RD, et al. Biochim Biophys Acta, 2005 May 25. PMID 15794922

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-glucosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dolichyl-phosphate beta-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-phosphate beta-glucosyltransferase
    NP_015097.1
    • UDP-glucose:dolichyl-phosphate glucosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum; human ortholog ALG5 can partially complement yeast alg5 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      120163..121167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184041.1 → NP_015097.1  TPA: dolichyl-phosphate beta-glucosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015097.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3E3, P40350
      UniProtKB/TrEMBL
      C7GU66, G2WNV8, N1P2K3
      Conserved Domains (1) summary
      cd04188
      Location:77 → 302
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40350.1

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