U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Il10rb interleukin 10 receptor subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304091, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Il10rbprovided by RGD
    Official Full Name
    interleukin 10 receptor subunit betaprovided by RGD
    Primary source
    RGD:1560373
    See related
    EnsemblRapid:ENSRNOG00000028638 AllianceGenome:RGD:1560373
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560373
    Summary
    Predicted to enable coreceptor activity and interleukin-10 receptor activity. Predicted to be involved in interleukin-10-mediated signaling pathway; positive regulation of cellular respiration; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 112.5), Lung (RPKM 100.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Il10rb in Genome Data Viewer
    Location:
    11q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (44132471..44154062)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (30646494..30668081)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (31560301..31582457)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481055 Neighboring gene uncharacterized LOC120095615 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene uncharacterized LOC120095617 Neighboring gene uncharacterized LOC120095616 Neighboring gene uncharacterized LOC102554317

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. Spencer SD, et al. J Exp Med, 1998 Feb 16. PMID 9463407, Free PMC Article
    2. Ileal immune dysregulation in necrotizing enterocolitis: role of CD40/CD40L in the pathogenesis of disease. Xu J, et al. J Pediatr Gastroenterol Nutr, 2011 Feb. PMID 21240009
    3. Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor. Sivula J, et al. BMC Immunol, 2009 May 4. PMID 19409109, Free PMC Article
    4. Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex. Yoon SI, et al. J Biol Chem, 2006 Nov 17. PMID 16982608
    5. Biology of interleukin-10. Sabat R, et al. Cytokine Growth Factor Rev, 2010 Oct. PMID 21115385

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-10 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interleukin-10-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    interleukin 10 receptor, beta

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107111.1 → NP_001100581.1  interleukin-10 receptor subunit beta precursor

      See identical proteins and their annotated locations for NP_001100581.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473989
      UniProtKB/TrEMBL
      A6JLF1, D3ZM36
      Conserved Domains (2) summary
      pfam09294
      Location:113 → 215
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:23 → 102
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      44132471..44154062
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270594.1 → XP_063126664.1  interleukin-10 receptor subunit beta isoform X7

    2. XM_006248062.5 → XP_006248124.1  interleukin-10 receptor subunit beta isoform X3

      UniProtKB/TrEMBL
      D3ZM36
      Related
      ENSRNOP00000102884.1, ENSRNOT00000147658.1
      Conserved Domains (2) summary
      pfam09294
      Location:113 → 215
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:23 → 102
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_063270593.1 → XP_063126663.1  interleukin-10 receptor subunit beta isoform X6

    4. XM_063270590.1 → XP_063126660.1  interleukin-10 receptor subunit beta isoform X1

    5. XM_063270591.1 → XP_063126661.1  interleukin-10 receptor subunit beta isoform X2

      UniProtKB/TrEMBL
      A6JLF2
      Related
      ENSRNOP00000058062.5, ENSRNOT00000061345.5

    6. XM_006248063.5 → XP_006248125.1  interleukin-10 receptor subunit beta isoform X4

      UniProtKB/TrEMBL
      D3ZM36
      Related
      ENSRNOP00000110332.1, ENSRNOT00000140116.1
      Conserved Domains (2) summary
      pfam09294
      Location:92 → 194
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:2 → 81
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    7. XM_063270592.1 → XP_063126662.1  interleukin-10 receptor subunit beta isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools