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    Slco4a1 solute carrier organic anion transporter family, member 4a1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171144, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Slco4a1provided by RGD
    Official Full Name
    solute carrier organic anion transporter family, member 4a1provided by RGD
    Primary source
    RGD:620228
    See related
    EnsemblRapid:ENSRNOG00000053430 AllianceGenome:RGD:620228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    OATP-E; Slc21a12
    Summary
    Enables thyroid hormone transmembrane transporter activity. Involved in thyroid hormone metabolic process. Predicted to be located in plasma membrane. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO4A1 (solute carrier organic anion transporter family member 4A1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 38.5), Spleen (RPKM 14.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slco4a1 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (187936735..187955873)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (167559177..167578307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (175838994..175857985)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene microRNA 1b Neighboring gene uncharacterized LOC108350538 Neighboring gene uncharacterized LOC134486516 Neighboring gene uncharacterized LOC134486515 Neighboring gene uncharacterized LOC102552550 Neighboring gene neurotensin receptor 1 Neighboring gene 60S ribosomal protein L17-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Fujiwara K, et al. Endocrinology, 2001 May. PMID 11316767
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables prostaglandin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables prostaglandin transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thyroid hormone transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thyroid hormone transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 4A1
    Names
    organic anion-transporting polypeptide E
    sodium-independent organic anion transporter E
    solute carrier family 21 (organic anion transporter), member 12
    solute carrier family 21 member 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133608.2 → NP_598292.2  solute carrier organic anion transporter family member 4A1

      See identical proteins and their annotated locations for NP_598292.2

      Status: PROVISIONAL

      Source sequence(s)
      BC097285
      UniProtKB/Swiss-Prot
      Q99N01
      UniProtKB/TrEMBL
      A0A0G2K8R0, Q4V8N6
      Related
      ENSRNOP00000074703.1, ENSRNOT00000080656.3
      Conserved Domains (3) summary
      cd06174
      Location:105 → 340
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:502 → 556
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:103 → 665
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      187936735..187955873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104197.2 → XP_038960125.1  solute carrier organic anion transporter family member 4A1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:101 → 427
      MFS; Major Facilitator Superfamily

    2. XM_039104196.2 → XP_038960124.1  solute carrier organic anion transporter family member 4A1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:101 → 484
      MFS; Major Facilitator Superfamily

    3. XM_017591449.2 → XP_017446938.1  solute carrier organic anion transporter family member 4A1 isoform X1

      UniProtKB/Swiss-Prot
      Q99N01
      UniProtKB/TrEMBL
      A0A0G2K8R0, Q4V8N6
      Conserved Domains (3) summary
      cd06174
      Location:105 → 340
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:502 → 556
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:103 → 665
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    4. XM_063283042.1 → XP_063139112.1  solute carrier organic anion transporter family member 4A1 isoform X4

    RNA

    1. XR_005501764.2 RNA Sequence

    2. XR_005501765.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N01.1 GenPept UniProtKB/Swiss-Prot:Q99N01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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