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    Naa30 N(alpha)-acetyltransferase 30, NatC catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498489, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Naa30provided by RGD
    Official Full Name
    N(alpha)-acetyltransferase 30, NatC catalytic subunitprovided by RGD
    Primary source
    RGD:1559923
    See related
    EnsemblRapid:ENSRNOG00000014192 AllianceGenome:RGD:1559923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nat12; RGD1559923
    Summary
    Predicted to enable peptide alpha-N-acetyltransferase activity. Predicted to be involved in protein stabilization. Predicted to be located in cytosol and nucleus. Predicted to be part of NatC complex. Orthologous to human NAA30 (N-alpha-acetyltransferase 30, NatC catalytic subunit). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Heart (RPKM 108.3), Muscle (RPKM 103.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Naa30 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (24935060..24954435)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (22454914..22474789)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (26032760..26052774)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene exocyst complex component 5 Neighboring gene adaptor related protein complex 5 subunit mu 1 Neighboring gene coiled-coil domain containing 198 Neighboring gene solute carrier family 35, member F4 Neighboring gene uncharacterized LOC102556222 Neighboring gene transcription initiation factor IIA subunit 2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. Aksnes H, et al. Cell Rep, 2015 Mar 3. PMID 25732826
    2. Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization. Starheim KK, et al. Mol Cell Biol, 2009 Jul. PMID 19398576, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptide alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-methionine acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 30
    Names
    N-acetyltransferase 12 (GCN5-related, putative)
    NP_001102569.1
    XP_006251875.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109099.1 → NP_001102569.1  N-alpha-acetyltransferase 30

      See identical proteins and their annotated locations for NP_001102569.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474040
      UniProtKB/TrEMBL
      A6KE85, D3ZWS6
      Related
      ENSRNOP00000020074.6, ENSRNOT00000020074.7
      Conserved Domains (2) summary
      COG0456
      Location:209 → 362
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:281 → 339
      Acetyltransf_1; Acetyltransferase (GNAT) family

    2. NM_001431591.1 → NP_001418520.1  N-alpha-acetyltransferase 30

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KE85

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      24935060..24954435
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251813.5 → XP_006251875.1  N-alpha-acetyltransferase 30 isoform X1

      Conserved Domains (2) summary
      COG0456
      Location:209 → 362
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:281 → 339
      Acetyltransf_1; Acetyltransferase (GNAT) family
    Nucleotide Protein Strain
    Heading Accession and Version

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