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    LCB3 sphinganine kinase LCB3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853307, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LCB3
    Official Full Name
    sphinganine kinase LCB3
    Primary source
    SGD:S000003670
    Locus tag
    YJL134W
    See related
    AllianceGenome:SGD:S000003670; FungiDB:YJL134W; VEuPathDB:YJL134W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LBP1; YSR2
    Summary
    Enables sphingosine-1-phosphate phosphatase activity. Involved in calcium-mediated signaling. Located in endoplasmic reticulum. Orthologous to human SGPP1 (sphingosine-1-phosphate phosphatase 1) and SGPP2 (sphingosine-1-phosphate phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LCB3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (158188..159417)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S21B Neighboring gene Dpi8p Neighboring gene Fe(2+) transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p. Kihara A, et al. Genes Cells, 2003 Jun. PMID 12786943
    2. Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. Qie L, et al. J Biol Chem, 1997 Jun 27. PMID 9195906
    3. Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. Kharel Y, et al. PLoS One, 2018. PMID 29672528, Free PMC Article
    4. Yeast sphingosine-1-phosphate phosphatases: assay, expression, deletion, purification, and cellular localization by GFP tagging. Mao C, et al. Methods Enzymol, 2000. PMID 10563329
    5. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Mao C, et al. Biochem J, 1999 Sep 15. PMID 10477278, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dihydrosphingosine-1-phosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine-1-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sphinganine kinase LCB3
    NP_012401.1
    • Long-chain base-1-phosphate phosphatase; specific for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids; LCB3 has a paralog, YSR3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      158188..159417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181567.1 → NP_012401.1  TPA: sphinganine kinase LCB3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012401.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW50, P47013
      UniProtKB/TrEMBL
      B3LPY3, B5VL43, C7GPZ4, D3UF55, G2WGN6
      Conserved Domains (1) summary
      cd03388
      Location:77 → 230
      PAP2_SPPase1; PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47013.1

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