CAMK1 calcium/calmodulin dependent protein kinase I [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAMK1provided by HGNC
Official Full Name: calcium/calmodulin dependent protein kinase Iprovided by HGNC
Primary source: HGNC:HGNC:1459
See related: Ensembl:ENSG00000134072 MIM:604998; AllianceGenome:HGNC:1459
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CAMKI
Summary: Calcium/calmodulin-dependent protein kinase I is expressed in many tissues and is a component of a calmodulin-dependent protein kinase cascade. Calcium/calmodulin directly activates calcium/calmodulin-dependent protein kinase I by binding to the enzyme and indirectly promotes the phosphorylation and synergistic activation of the enzyme by calcium/calmodulin-dependent protein kinase I kinase. [provided by RefSeq, Jul 2008]
Expression: Broad expression in adrenal (RPKM 42.3), fat (RPKM 25.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3p25.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (9757347..9769947, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (9749303..9761902, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (9799031..9811631, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
Title: Expression of CAMK1 and its association with clinicopathologic characteristics in pancreatic cancer.
The mRNA expressions of PPP3CB and MEF2C were significantly up-regulated, and CAMK1 and PPP3R1 were significantly down-regulated in mitral regurgitation(MR) patients compared to normal subjects. Moreover, MR patients had significantly increased mRNA levels of PPP3CB, MEF2C and PLCE1 compared to aortic valve disease patients
Title: Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy.
Barettin has inhibitory activity against two protein kinases related to inflammation, namely the receptor-interacting serine/threonine kinase 2 (RIPK2) and calcium/calmodulin-dependent protein kinase 1alpha (CAMK1alpha).
Title: The immunomodulatory effects of barettin and involvement of the kinases CAMK1α and RIPK2.
CAMK1 functional regulation subnetwork in hepatocellular carcinoma
Title: CAMK1 phosphoinositide signal-mediated protein sorting and transport network in human hepatocellular carcinoma (HCC) by biocomputation.
this study suggests that the tightly linked regulatory loop comprised of the SIK2-PP2A and CaMKI and PME-1 networks may function in fine-tuning cell proliferation and stress response.
Title: Interaction between salt-inducible kinase 2 and protein phosphatase 2A regulates the activity of calcium/calmodulin-dependent protein kinase I and protein phosphatase methylesterase-1.
It is one of Ca(2+)-sensing proteins and substantial age- and Alzheimer disease(AD)-related alterations in Ca(2+)-sensing proteins most likely contribute to selective vulnerability of basal forebrain cholinergic neurons to degeneration in AD.
Title: Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease.
Fbxl12-induced CaMKI degradation attenuates p27 phosphorylation at these sites in early G1 and iii) activation of CaMKI during G1 transition followed by p27 phosphorylation appears to be upstream to other p27 phosphorylation events
Title: Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I.
structures of three CaMKIalpha truncates in apo form and in complexes with ATP
Title: Crystal structures of human CaMKIα reveal insights into the regulation mechanism of CaMKI.
CaMKI was significantly upregulated in adrenal adenomas.
Title: Aldosterone producing adrenal adenomas are characterized by activation of calcium/calmodulin-dependent protein kinase (CaMK) dependent pathways.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways	PubMed
Tat	tat	HIV-1 Tat-peptide(48-60) inhibits AGC-family kinases (PKB, SGK1, S6K1, MSK1), CAMK-family kinases (CAMK1 and MELK) and a STE family kinase (MKK1)	PubMed
	tat	Microarray analysis indicates HIV-1 Tat downregulates the expression of many proteins, including CAMK1, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-79567 (e-PCR)
- UniSTS:103687

RH78923 (e-PCR)
- UniSTS:72512

G67289 (e-PCR)
- UniSTS:186454

SHGC-76687 (e-PCR)
- UniSTS:52834

NoName (e-PCR)
- UniSTS:484775

SHGC-76689 (e-PCR)
- UniSTS:34774

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse structural plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of syncytium formation by plasma membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type 1

Names: caM kinase I alpha; caM-KI; caMKI-alpha

NP_003647.1

EC 2.7.11.17

XP_005265573.1

EC 2.7.11.17

XP_005265574.1

EC 2.7.11.17

XP_016862843.1

EC 2.7.11.17

XP_047305045.1

EC 2.7.11.17

XP_054204127.1

EC 2.7.11.17

XP_054204128.1

EC 2.7.11.17

XP_054204129.1

EC 2.7.11.17

XP_054204130.1

EC 2.7.11.17

XP_054204131.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003656.5 → NP_003647.1 calcium/calmodulin-dependent protein kinase type 1

See identical proteins and their annotated locations for NP_003647.1

Status: REVIEWED

Source sequence(s)

AA724193, BC106754, DN990042

Consensus CDS

CCDS2582.1

UniProtKB/Swiss-Prot

Q14012, Q3KPF6

UniProtKB/TrEMBL

A0A024R2D6, B0YIY3, B5BU41

Related

ENSP00000256460.3, ENST00000256460.8

Conserved Domains (1) summary

cd14167
Location:16 → 278

STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

9757347..9769947 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017007354.2 → XP_016862843.1 calcium/calmodulin-dependent protein kinase type 1 isoform X3

UniProtKB/TrEMBL

B5BU41

Conserved Domains (2) summary

smart00220
Location:8 → 232

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 234

PKc_like; Protein Kinases, catalytic domain
XM_005265517.4 → XP_005265574.1 calcium/calmodulin-dependent protein kinase type 1 isoform X2

UniProtKB/TrEMBL

B5BU41

Conserved Domains (2) summary

smart00220
Location:8 → 232

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 231

PKc_like; Protein Kinases, catalytic domain
XM_005265516.3 → XP_005265573.1 calcium/calmodulin-dependent protein kinase type 1 isoform X1

UniProtKB/TrEMBL

B5BU41

Conserved Domains (2) summary

smart00220
Location:20 → 276

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14167
Location:16 → 278

STKc_CaMKI_alpha; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha
XM_047449089.1 → XP_047305045.1 calcium/calmodulin-dependent protein kinase type 1 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

9749303..9761902 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054348155.1 → XP_054204130.1 calcium/calmodulin-dependent protein kinase type 1 isoform X3
XM_054348153.1 → XP_054204128.1 calcium/calmodulin-dependent protein kinase type 1 isoform X2
XM_054348152.1 → XP_054204127.1 calcium/calmodulin-dependent protein kinase type 1 isoform X1
XM_054348154.1 → XP_054204129.1 calcium/calmodulin-dependent protein kinase type 1 isoform X5
XM_054348156.1 → XP_054204131.1 calcium/calmodulin-dependent protein kinase type 1 isoform X4