SRPK2 SRSF protein kinase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SRPK2provided by HGNC
Official Full Name: SRSF protein kinase 2provided by HGNC
Primary source: HGNC:HGNC:11306
See related: Ensembl:ENSG00000135250 MIM:602980; AllianceGenome:HGNC:11306
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SFRSK2
Summary: Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including R-loop processing; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.3

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (105114740..105399357, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (106428390..106713586, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (104756821..105029838, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.
Title: SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.
The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
Title: The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Title: Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis.
Title: Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis.
SRPK1/2 and PP1alpha exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
Title: SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Title: Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
Title: Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
SRPK2 expression was upregulated in pancreatic cancer tissues, positively correlated with stage, and associated with decreased overall survival in pancreatic cancer patients. In pancreatic cancer cells, SRPK2 overexpression promoted cell invasion and migration, and decreased chemosensitivity to gemcitabine or oxaliplatin. SRPK2 silencing decreased cell invasion and migration and increased chemosensitivity.
Title: Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
The conserved SRPK-specific substrate-docking groove in SRPK2 impacts the binding and phosphorylation of both SR proteins, and the localization of SRSF3.
Title: Distinct mechanisms govern the phosphorylation of different SR protein splicing factors.
SRPK2 may play an important role in the progression and metastasis of prostate cancer.
Title: Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D7S2731 (e-PCR)
- UniSTS:25383

SHGC-57147 (e-PCR)
- UniSTS:41768

RH120258 (e-PCR)
- UniSTS:132714

D7S1656 (e-PCR)
- UniSTS:59002

D7S1389 (e-PCR)
- UniSTS:33923

SHGC-84676 (e-PCR)
- UniSTS:104077

WI-20562 (e-PCR)
- UniSTS:42902

D7S2926 (e-PCR)
- UniSTS:42903

D7S2731 (e-PCR)
- UniSTS:69801

RH79016 (e-PCR)
- UniSTS:63931

D7S2182 (e-PCR)
- UniSTS:35524

SRPK2_8645 (e-PCR)
- UniSTS:471772

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	HDA more info	PubMed
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in R-loop processing	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IC Inferred by Curator more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear speck organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-serine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of viral genome replication	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mRNA splicing, via spliceosome	TAS Traceable Author Statement more info	PubMed
involved_in spliceosomal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal complex assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SRSF protein kinase 2

Names: SFRS protein kinase 2; SR protein kinase 2; SR-protein-specific kinase 2; serine kinase SRPK2; serine/arginine-rich protein-specific kinase 2; serine/arginine-rich splicing factor kinase 2; serine/threonine-protein kinase SRPK2

NP_001265202.1

EC 2.7.11.1

NP_001337667.1

EC 2.7.11.1

NP_001337668.1

EC 2.7.11.1

NP_001337669.1

EC 2.7.11.1

NP_001337670.1

EC 2.7.11.1

NP_001337671.1

EC 2.7.11.1

NP_001337672.1

EC 2.7.11.1

NP_001337673.1

EC 2.7.11.1

NP_001337674.1

EC 2.7.11.1

NP_001337675.1

EC 2.7.11.1

NP_872633.1

EC 2.7.11.1

NP_872634.1

EC 2.7.11.1

XP_006716161.1

EC 2.7.11.1

XP_011514838.1

EC 2.7.11.1

XP_011514840.1

EC 2.7.11.1

XP_016868050.2

EC 2.7.11.1

XP_024302661.1

EC 2.7.11.1

XP_024302662.1

EC 2.7.11.1

XP_024302663.1

EC 2.7.11.1

XP_047276728.1

EC 2.7.11.1

XP_047276729.1

EC 2.7.11.1

XP_047276730.1

EC 2.7.11.1

XP_047276731.1

EC 2.7.11.1

XP_047276732.1

EC 2.7.11.1

XP_054214855.1

EC 2.7.11.1

XP_054214856.1

EC 2.7.11.1

XP_054214857.1

EC 2.7.11.1

XP_054214858.1

EC 2.7.11.1

XP_054214859.1

EC 2.7.11.1

XP_054214860.1

EC 2.7.11.1

XP_054214861.1

EC 2.7.11.1

XP_054214862.1

EC 2.7.11.1

XP_054214863.1

EC 2.7.11.1

XP_054214864.1

EC 2.7.11.1

XP_054214865.1

EC 2.7.11.1

XP_054214866.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278273.2 → NP_001265202.1 SRSF protein kinase 2 isoform b precursor

See identical proteins and their annotated locations for NP_001265202.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC004884, AC005070, BC035214, BC068547, BU632662

Consensus CDS

CCDS5735.1

UniProtKB/Swiss-Prot

A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3

UniProtKB/TrEMBL

H7C5L6

Related

ENSP00000419791.1, ENST00000489828.5

Conserved Domains (2) summary

cl21453
Location:68 → 256

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350738.2 → NP_001337667.1 SRSF protein kinase 2 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.

Source sequence(s)

AC004884, AC005070, AC073138

Consensus CDS

CCDS5735.1

UniProtKB/Swiss-Prot

A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3

UniProtKB/TrEMBL

H7C5L6

Conserved Domains (2) summary

cl21453
Location:68 → 256

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350739.2 → NP_001337668.1 SRSF protein kinase 2 isoform c

Status: VALIDATED

Source sequence(s)

AC004884, AC005070

UniProtKB/TrEMBL

H7C5L6

Conserved Domains (3) summary

cd14217
Location:68 → 256

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:504 → 686

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350740.2 → NP_001337669.1 SRSF protein kinase 2 isoform d

Status: VALIDATED

Description

Transcript Variant: This variant (6) encodes the longest isoform (d).

Source sequence(s)

AC005070, AC073138

Conserved Domains (3) summary

cd14217
Location:116 → 304

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:552 → 734

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:389 → 431

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350741.2 → NP_001337670.1 SRSF protein kinase 2 isoform e

Status: VALIDATED

Source sequence(s)

AC005070, AC073138

UniProtKB/TrEMBL

H7C5L6

Conserved Domains (2) summary

cl21453
Location:79 → 267

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:352 → 394

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350742.2 → NP_001337671.1 SRSF protein kinase 2 isoform f

Status: VALIDATED

Source sequence(s)

AC004884, AC005070, AC073138

Consensus CDS

CCDS94172.1

UniProtKB/TrEMBL

A0A994J591, H7C5L6

Related

ENSP00000516319.1, ENST00000482862.2

Conserved Domains (3) summary

cd14217
Location:105 → 293

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:541 → 723

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:378 → 420

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350743.2 → NP_001337672.1 SRSF protein kinase 2 isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.

Source sequence(s)

AC004884, AC005070, AC073138

Consensus CDS

CCDS94171.1

UniProtKB/TrEMBL

C9J2M4, H7C5L6

Related

ENSP00000417357.2, ENST00000460391.6

Conserved Domains (3) summary

cd14217
Location:68 → 256

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:504 → 717

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350744.2 → NP_001337673.1 SRSF protein kinase 2 isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.

Source sequence(s)

AC004884, AC005070

Consensus CDS

CCDS94171.1

UniProtKB/TrEMBL

C9J2M4, H7C5L6

Conserved Domains (3) summary

cd14217
Location:68 → 256

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:504 → 717

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_001350745.2 → NP_001337674.1 SRSF protein kinase 2 isoform h

Status: VALIDATED

Source sequence(s)

AC004884, AC005070

UniProtKB/TrEMBL

H7C5L6

Conserved Domains (1) summary

cl21453
Location:70 → 640

PKc_like; Protein Kinases, catalytic domain
NM_001350746.2 → NP_001337675.1 SRSF protein kinase 2 isoform i

Status: VALIDATED

Source sequence(s)

AC004884, AC005070, AC073138

Conserved Domains (3) summary

cd14217
Location:105 → 293

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:545 → 610

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:378 → 420

Na_Ca_ex; Sodium/calcium exchanger protein
NM_182691.3 → NP_872633.1 SRSF protein kinase 2 isoform b precursor

See identical proteins and their annotated locations for NP_872633.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

BC035214, BU632662, CR746049, DA592321

Consensus CDS

CCDS5735.1

UniProtKB/Swiss-Prot

A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3

UniProtKB/TrEMBL

H7C5L6

Related

ENSP00000349863.3, ENST00000357311.7

Conserved Domains (2) summary

cl21453
Location:68 → 256

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
NM_182692.3 → NP_872634.1 SRSF protein kinase 2 isoform a

See identical proteins and their annotated locations for NP_872634.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

BC035214, BU632662, CR746049, HY031357

Consensus CDS

CCDS34724.1

UniProtKB/TrEMBL

H7C5L6

Related

ENSP00000377262.3, ENST00000393651.8

Conserved Domains (2) summary

smart00220
Location:92 → 236

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:79 → 267

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

105114740..105399357 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011516536.4 → XP_011514838.1 SRSF protein kinase 2 isoform X5

UniProtKB/TrEMBL

H7C5L6

Conserved Domains (2) summary

cd14217
Location:79 → 267

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:515 → 728

PKc_like; Protein Kinases, catalytic domain
XM_011516538.3 → XP_011514840.1 SRSF protein kinase 2 isoform X6

See identical proteins and their annotated locations for XP_011514840.1

UniProtKB/TrEMBL

C9J2M4, H7C5L6

Conserved Domains (3) summary

cd14217
Location:68 → 256

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:504 → 717

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
XM_024446895.2 → XP_024302663.1 SRSF protein kinase 2 isoform X4

Conserved Domains (3) summary

cd14217
Location:116 → 304

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:552 → 734

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:389 → 431

Na_Ca_ex; Sodium/calcium exchanger protein
XM_024446894.2 → XP_024302662.1 SRSF protein kinase 2 isoform X3

Conserved Domains (3) summary

cd14217
Location:116 → 304

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:552 → 765

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:389 → 431

Na_Ca_ex; Sodium/calcium exchanger protein
XM_017012561.3 → XP_016868050.2 SRSF protein kinase 2 isoform X2

UniProtKB/TrEMBL

H7C5L6

Conserved Domains (3) summary

cd14217
Location:105 → 293

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:541 → 723

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:378 → 420

Na_Ca_ex; Sodium/calcium exchanger protein
XM_024446893.2 → XP_024302661.1 SRSF protein kinase 2 isoform X1

Conserved Domains (3) summary

cd14217
Location:105 → 293

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:541 → 754

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:378 → 420

Na_Ca_ex; Sodium/calcium exchanger protein
XM_047420772.1 → XP_047276728.1 SRSF protein kinase 2 isoform X6

UniProtKB/TrEMBL

C9J2M4
XM_047420776.1 → XP_047276732.1 SRSF protein kinase 2 isoform X9
XM_047420773.1 → XP_047276729.1 SRSF protein kinase 2 isoform X7
XM_047420774.1 → XP_047276730.1 SRSF protein kinase 2 isoform X8

Related

ENSP00000420208.2, ENST00000477925.6
XM_006716098.4 → XP_006716161.1 SRSF protein kinase 2 isoform X6

See identical proteins and their annotated locations for XP_006716161.1

UniProtKB/TrEMBL

C9J2M4, H7C5L6

Conserved Domains (3) summary

cd14217
Location:68 → 256

STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2

cl21453
Location:504 → 717

PKc_like; Protein Kinases, catalytic domain

cl27511
Location:341 → 383

Na_Ca_ex; Sodium/calcium exchanger protein
XM_047420775.1 → XP_047276731.1 SRSF protein kinase 2 isoform X8

RNA

XR_007060151.1 RNA Sequence
XR_007060150.1 RNA Sequence
XR_007060147.1 RNA Sequence
XR_001744862.3 RNA Sequence
XR_007060153.1 RNA Sequence
XR_007060148.1 RNA Sequence
XR_007060149.1 RNA Sequence
XR_001744863.3 RNA Sequence
XR_001744861.3 RNA Sequence
XR_007060152.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

106428390..106713586 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054358884.1 → XP_054214859.1 SRSF protein kinase 2 isoform X5
XM_054358887.1 → XP_054214862.1 SRSF protein kinase 2 isoform X6

UniProtKB/TrEMBL

C9J2M4
XM_054358883.1 → XP_054214858.1 SRSF protein kinase 2 isoform X4
XM_054358882.1 → XP_054214857.1 SRSF protein kinase 2 isoform X3
XM_054358881.1 → XP_054214856.1 SRSF protein kinase 2 isoform X2
XM_054358880.1 → XP_054214855.1 SRSF protein kinase 2 isoform X1
XM_054358886.1 → XP_054214861.1 SRSF protein kinase 2 isoform X6

UniProtKB/TrEMBL

C9J2M4
XM_054358891.1 → XP_054214866.1 SRSF protein kinase 2 isoform X9
XM_054358888.1 → XP_054214863.1 SRSF protein kinase 2 isoform X7
XM_054358889.1 → XP_054214864.1 SRSF protein kinase 2 isoform X8
XM_054358885.1 → XP_054214860.1 SRSF protein kinase 2 isoform X6

UniProtKB/TrEMBL

C9J2M4
XM_054358890.1 → XP_054214865.1 SRSF protein kinase 2 isoform X8