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    YJR096W aldo-keto reductase superfamily protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853559, updated on 4-Aug-2024

    Summary

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    Gene symbol
    YJR096W
    Gene description
    aldo-keto reductase superfamily protein
    Primary source
    FungiDB:YJR096W
    Locus tag
    YJR096W
    See related
    SGD:S000003857; AllianceGenome:SGD:S000003857; VEuPathDB:YJR096W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alditol:NADP+ 1-oxidoreductase activity. Involved in D-xylose catabolic process; arabinose catabolic process; and cellular response to oxidative stress. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YJR096W in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (611195..612043)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L43B Neighboring gene Sfc1p Neighboring gene Jjj3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases. Calam E, et al. Chem Biol Interact, 2013 Feb 25. PMID 23295224
    2. Putative xylose and arabinose reductases in Saccharomyces cerevisiae. Träff KL, et al. Yeast, 2002 Oct. PMID 12271459
    3. Identification and functional evaluation of the reductases and dehydrogenases from Saccharomyces cerevisiae involved in vanillin resistance. Wang X, et al. BMC Biotechnol, 2016 Apr 1. PMID 27036139, Free PMC Article
    4. Disruption of aldo-keto reductase genes leads to elevated markers of oxidative stress and inositol auxotrophy in Saccharomyces cerevisiae. Chang Q, et al. Biochim Biophys Acta, 2008 Feb. PMID 17919749, Free PMC Article
    5. Functional studies of aldo-keto reductases in Saccharomyces cerevisiae. Chang Q, et al. Biochim Biophys Acta, 2007 Mar. PMID 17140678, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aldose reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldose reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-xylose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in arabinose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arabinose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    aldo-keto reductase superfamily protein
    NP_012630.1
    • Xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      611195..612043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181754.1 → NP_012630.1  TPA: aldo-keto reductase superfamily protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012630.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWR5, P47137
      UniProtKB/TrEMBL
      A6ZQ52, B3LQI1, C7GMB1, C8ZBP3, N1P073
      Conserved Domains (1) summary
      cd19071
      Location:14 → 266
      AKR_AKR1-5-like; AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47137.1

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