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    IgG-2a gamma-2a immunoglobulin heavy chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367586, updated on 2-Nov-2024

    Summary

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    Symbol
    IgG-2aprovided by RGD
    Full Name
    gamma-2a immunoglobulin heavy chainprovided by RGD
    Primary source
    RGD:1359626
    See related
    AllianceGenome:RGD:1359626
    Gene type
    protein coding
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Predicted to be part of immunoglobulin complex, circulating. Orthologous to several human genes including IGHG1 (immunoglobulin heavy constant gamma 1 (G1m marker)); IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker)); and IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    not in current annotation release
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    Genomic context

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    Location:
    6q32

    Bibliography

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    Related articles in PubMed

    1. Evolution of the rat immunoglobulin gamma heavy-chain gene family. Brüggemann M. Gene, 1988 Dec 30. PMID 3149946
    2. Immunoglobulin heavy chain locus of the rat: striking homology to mouse antibody genes. Brüggemann M, et al. Proc Natl Acad Sci U S A, 1986 Aug. PMID 3016742, Free PMC Article
    3. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • Ig gamma-2a-chain
    • immunoglobulin gamma-2a chain

    Clone Names

    • MGC109083, MGC109134

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables immunoglobulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation, classical pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of immunoglobulin complex, circulating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Names
    gamma-2a immunoglobulin heavy chain
    Ig gamma-2a-chain
    immunoglobulin gamma-2a chain

    NCBI Reference Sequences (RefSeq)

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    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014081.1: Suppressed sequence

      Description
      NM_001014081.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version

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