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    Grsf1 G-rich RNA sequence binding factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 231413, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Grsf1provided by MGI
    Official Full Name
    G-rich RNA sequence binding factor 1provided by MGI
    Primary source
    MGI:MGI:106479
    See related
    Ensembl:ENSMUSG00000044221 AllianceGenome:MGI:106479
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Wsu31e
    Summary
    Predicted to enable RNA binding activity. Acts upstream of or within anterior/posterior pattern specification and morphogenesis of embryonic epithelium. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and sensory organ. Orthologous to human GRSF1 (G-rich RNA sequence binding factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 66.8), ovary adult (RPKM 32.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grsf1 in Genome Data Viewer
    Location:
    5 E1; 5 43.85 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (88807092..88824030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (88659233..88676171, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2748 Neighboring gene UTP3 small subunit processome component Neighboring gene predicted gene, 42107 Neighboring gene RUN and FYVE domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_13573 Neighboring gene STARR-seq mESC enhancer starr_13574 Neighboring gene STARR-seq mESC enhancer starr_13575 Neighboring gene STARR-seq mESC enhancer starr_13576 Neighboring gene STARR-seq mESC enhancer starr_13577 Neighboring gene MOB kinase activator 1B Neighboring gene predicted gene 15682 Neighboring gene STARR-positive B cell enhancer ABC_E1682 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:89195274-89195480 Neighboring gene deoxycytidine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Male guanine-rich RNA sequence binding factor 1 knockout mice (Grsf1(-/-)) gain less body weight during adolescence and adulthood. Dumoulin B, et al. Cell Biosci, 2022 Dec 9. PMID 36494688, Free PMC Article
    2. Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production. Yin W, et al. Exp Cell Res, 2019 Aug 1. PMID 31085189
    3. Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis. Li Y, et al. Mol Neurobiol, 2024 Apr. PMID 37861894
    4. Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development. Ufer C, et al. Genes Dev, 2008 Jul 1. PMID 18593884, Free PMC Article
    5. GRSF1 is an age-related regulator of senescence. Kim SJ, et al. Sci Rep, 2019 Apr 3. PMID 30944385, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.
      Title: Anti-aging Factor GRSF1 Attenuates Cerebral Ischemia-Reperfusion Injury in Mice by Inhibiting GPX4-Mediated Ferroptosis.
    2. GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.
      Title: GRSF1 deficiency in skeletal muscle reduces endurance in aged mice.
    3. GRSF1 is an age-related regulator of senescence.
      Title: GRSF1 is an age-related regulator of senescence.
    4. GRSF1 has a negative role in muscle differentiation
      Title: Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production.
    5. Grsf1 controls translation of the protein Use1, possibly by positioning the 40S ribosomal subunit and associated translation factors in front of the translation start site.
      Title: Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
    6. Grsf1 up-regulates translation of GPx4 mRNA and implicate the two proteins in embryonic brain development.
      Title: Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development.
    7. Grsf1 is important for axial elongation, mid/hindbrain development and axial mesoderm specification.
      Title: Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • B130010H02

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial RNA catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitochondrial RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    G-rich sequence factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098476.2 → NP_001091946.1  G-rich sequence factor 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121541, AC160533, AK077782, AK168385, CK391158
      Consensus CDS
      CCDS51540.1
      UniProtKB/TrEMBL
      E9Q179, Q8C298
      Related
      ENSMUSP00000108860.2, ENSMUST00000113234.8
      Conserved Domains (3) summary
      cd12505
      Location:131 → 204
      RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12730
      Location:31 → 109
      RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12733
      Location:283 → 357
      RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

    2. NM_178700.5 → NP_848815.2  G-rich sequence factor 1 isoform 1

      See identical proteins and their annotated locations for NP_848815.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC121541, AK044889, AK045986, AK077782
      Consensus CDS
      CCDS19404.1
      UniProtKB/Swiss-Prot
      Q8BR05, Q8BRG7, Q8C5Q4
      Related
      ENSMUSP00000077972.6, ENSMUST00000078945.12
      Conserved Domains (4) summary
      COG0724
      Location:155 → 325
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12505
      Location:248 → 321
      RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12730
      Location:148 → 226
      RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12733
      Location:400 → 474
      RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      88807092..88824030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C5Q4.2 GenPept UniProtKB/Swiss-Prot:Q8C5Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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