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    Dync1i2 dynein cytoplasmic 1 intermediate chain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116659, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dync1i2provided by RGD
    Official Full Name
    dynein cytoplasmic 1 intermediate chain 2provided by RGD
    Primary source
    RGD:620174
    See related
    EnsemblRapid:ENSRNOG00000009781 AllianceGenome:RGD:620174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnci2; Dncic2
    Summary
    Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Involved in cellular response to nerve growth factor stimulus and negative regulation of neuron projection development. Predicted to be located in centrosome; microtubule; and vesicle. Predicted to be part of cytoplasmic dynein complex and outer dynein arm. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 298.2), Lung (RPKM 269.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dync1i2 in Genome Data Viewer
    Location:
    3q22
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76441621..76492782)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (56033882..56085080)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (57817677..57868854)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486105 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 28 Neighboring gene solute carrier family 25 member 12 Neighboring gene histone acetyltransferase 1 Neighboring gene U2 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84. Blasier KR, et al. J Neurosci Res, 2014 Sep. PMID 24798412, Free PMC Article
    2. Identification and developmental regulation of a neuron-specific subunit of cytoplasmic dynein. Pfister KK, et al. Mol Biol Cell, 1996 Feb. PMID 8688562, Free PMC Article
    3. Growth factor regulation of cytoplasmic dynein intermediate chain subunit expression preceding neurite extension. Salata MW, et al. J Neurosci Res, 2001 Sep 1. PMID 11536324
    4. Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains and p150Glued. Vaughan KT, et al. J Cell Biol, 1995 Dec. PMID 8522607, Free PMC Article
    5. Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells. Hirayama M, et al. Mol Cell Proteomics, 2013 May. PMID 23358504, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data of this study suggest that the IC-2C S84 has a role in modulating dynein properties.
      Title: Live cell imaging reveals differential modifications to cytoplasmic dynein properties by phospho- and dephosphomimic mutations of the intermediate chain 2C S84.
    2. Neurofibromatosis type I-related neural abnormalities are, in part, caused by up-regulation of dynein IC2-glucocorticoid receptor-COX-1 signaling.
      Title: Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in neurofibromatosis type I (NF1) disease model cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93277

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of outer dynein arm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cytoplasmic dynein 1 intermediate chain 2
    Names
    DH IC-2
    cytoplasmic dynein intermediate chain 2
    dynein intermediate chain 2, cytosolic
    dynein, cytoplasmic, intermediate chain 2
    dynein, cytoplasmic, intermediate polypeptide 2
    oncofetal protein (OFP)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270624.1 → NP_001257553.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

      See identical proteins and their annotated locations for NP_001257553.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC078764, CB733957, FM076575, FM110655, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62871, Q62872, Q62873
      UniProtKB/TrEMBL
      A6HM44, F7FJ03, Q6AZ35
      Conserved Domains (4) summary
      COG2319
      Location:323 → 593
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:129 → 157
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:333 → 371
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:270 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001270625.1 → NP_001257554.1  cytoplasmic dynein 1 intermediate chain 2 isoform 3

      See identical proteins and their annotated locations for NP_001257554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC078764, CB733957, FM076575, FM110655, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62871, Q62872, Q62873
      UniProtKB/TrEMBL
      A6HM45, D3ZU74
      Related
      ENSRNOP00000060919.4, ENSRNOT00000067729.6
      Conserved Domains (4) summary
      COG2319
      Location:303 → 573
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:109 → 137
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:313 → 351
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:250 → 572
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001429705.1 → NP_001416634.1  cytoplasmic dynein 1 intermediate chain 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM43, G3V9V3

    4. NM_001429706.1 → NP_001416635.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM44, F7FJ03, Q6AZ35

    5. NM_001429707.1 → NP_001416636.1  cytoplasmic dynein 1 intermediate chain 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM44, F7FJ03, Q6AZ35

    6. NM_001429708.1 → NP_001416637.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM45, D3ZU74

    7. NM_001429709.1 → NP_001416638.1  cytoplasmic dynein 1 intermediate chain 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HM45, D3ZU74

    8. NM_001429710.1 → NP_001416639.1  cytoplasmic dynein 1 intermediate chain 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    9. NM_001429711.1 → NP_001416640.1  cytoplasmic dynein 1 intermediate chain 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    10. NM_053880.2 → NP_446332.2  cytoplasmic dynein 1 intermediate chain 2 isoform 1

      See identical proteins and their annotated locations for NP_446332.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC078764, CB733957, FM076575, FM110655, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q62871, Q62872, Q62873
      UniProtKB/TrEMBL
      A6HM43, G3V9V3
      Related
      ENSRNOP00000042414.3, ENSRNOT00000047243.6
      Conserved Domains (3) summary
      COG2319
      Location:329 → 599
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:339 → 377
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:135 → 163
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      76441621..76492782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234346.5 → XP_006234408.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

      Related
      ENSRNOP00000110714.1, ENSRNOT00000144709.1
      Conserved Domains (4) summary
      COG2319
      Location:303 → 573
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:109 → 137
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:313 → 351
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:250 → 572
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039104115.2 → XP_038960043.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:329 → 599
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:339 → 377
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:135 → 163
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    3. XM_006234344.5 → XP_006234406.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

      Conserved Domains (4) summary
      COG2319
      Location:323 → 593
      WD40; WD40 repeat [General function prediction only]
      pfam11540
      Location:129 → 157
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2
      sd00039
      Location:333 → 371
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:270 → 592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_063283006.1 → XP_063139076.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

    5. XM_063283007.1 → XP_063139077.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

    6. XM_063283000.1 → XP_063139070.1  cytoplasmic dynein 1 intermediate chain 2 isoform X2

    7. XM_017591432.3 → XP_017446921.1  cytoplasmic dynein 1 intermediate chain 2 isoform X1

      UniProtKB/Swiss-Prot
      Q62871, Q62872, Q62873
      UniProtKB/TrEMBL
      A6HM43, G3V9V3
      Conserved Domains (3) summary
      COG2319
      Location:329 → 599
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:339 → 377
      7WD40; WD40 repeat [structural motif]
      pfam11540
      Location:135 → 163
      Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

    8. XM_063283003.1 → XP_063139073.1  cytoplasmic dynein 1 intermediate chain 2 isoform X5

      Related
      ENSRNOP00000101529.1, ENSRNOT00000154744.1

    9. XM_063283001.1 → XP_063139071.1  cytoplasmic dynein 1 intermediate chain 2 isoform X3

    10. XM_063283002.1 → XP_063139072.1  cytoplasmic dynein 1 intermediate chain 2 isoform X4

    11. XM_063283004.1 → XP_063139074.1  cytoplasmic dynein 1 intermediate chain 2 isoform X6

    12. XM_063283005.1 → XP_063139075.1  cytoplasmic dynein 1 intermediate chain 2 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62871.1 GenPept UniProtKB/Swiss-Prot:Q62871

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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