Eif4a2 eukaryotic translation initiation factor 4A2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eif4a2provided by RGD
Official Full Name: eukaryotic translation initiation factor 4A2provided by RGD
Primary source: RGD:1309225
See related: EnsemblRapid:ENSRNOG00000001815 AllianceGenome:RGD:1309225
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP hydrolysis activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and negative regulation of RNA-dependent RNA polymerase activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with hypotonia and speech delay. Orthologous to human EIF4A2 (eukaryotic translation initiation factor 4A2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 2426.5), Brain (RPKM 2289.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (91268730..91276738, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (77764126..77770810, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (81373047..81379680, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC139890P1 (e-PCR)
- UniSTS:270902

RH134436 (e-PCR)
- UniSTS:217716

Eif4a2 (e-PCR), detects polymorphism
- UniSTS:142980

UniSTS:237474 (e-PCR)
- UniSTS:237474

D20S1005 (e-PCR)
- UniSTS:154621

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of RNA-dependent RNA polymerase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of RNA-dependent RNA polymerase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic initiation factor 4A-II

Names: ATP-dependent RNA helicase eIF4A-2; eIF-4A-II; eIF4A-II; eukaryotic translation initiation factor 4A; protein synthesis initiation factor 4AII

NP_001008336.1

EC 3.6.4.13

XP_006248596.1

EC 3.6.4.13

XP_006248597.1

EC 3.6.4.13

XP_063126554.1

EC 3.6.4.13

XP_063126555.1

EC 3.6.4.13

XP_063126556.1

EC 3.6.4.13

XP_063126558.1

EC 3.6.4.13

XP_063126559.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.