Sparc secreted protein acidic and cysteine rich [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sparcprovided by RGD
Official Full Name: secreted protein acidic and cysteine richprovided by RGD
Primary source: RGD:3742
See related: EnsemblRapid:ENSRNOG00000012840 AllianceGenome:RGD:3742
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium ion binding activity. Involved in several processes, including response to L-ascorbic acid; response to cAMP; and response to lead ion. Located in extracellular space and vesicle. Is active in glutamatergic synapse. Biomarker of diabetic angiopathy; membranoproliferative glomerulonephritis; membranous glomerulonephritis; myocardial infarction; and stomach carcinoma. Human ortholog(s) of this gene implicated in cervix carcinoma; endometrial carcinoma; multiple myeloma; and osteogenesis imperfecta type 17. Orthologous to human SPARC (secreted protein acidic and cysteine rich). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 5728.7), Heart (RPKM 5380.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (40017065..40038816, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (39516394..39538252, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (40742390..40764232, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased Sparc release from subchondral osteoblasts promotes articular chondrocyte degeneration under estrogen withdrawal.
Title: Increased Sparc release from subchondral osteoblasts promotes articular chondrocyte degeneration under estrogen withdrawal.
Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization.
Title: Discoidin domain receptor 2 activation of p38 mitogen-activated protein kinase as an important pathway for osteonectin-regulating osteoblast mineralization.
miR-29b-3p plays an important role in the progression of heart failure through targeting SPARC and regulating TGFbeta1/Smad3 pathway.
Title: MicroRNA-29b-3p Targets SPARC Gene to Protect Cardiocytes against Autophagy and Apoptosis in Hypoxic-Induced H9c2 Cells.
Data suggest that reversion-inducing-cysteine-rich protein with kazal motifs (Reck) and SPARC Glycoprotein (Sparc) seem to play a role during ovarian dynamics: Reck as a possible inhibitor and Sparc as an inducer of matrix metalloproteinases (Mmps).
Title: Spatio-temporal expression profile of matrix metalloproteinase (Mmp) modulators Reck and Sparc during the rat ovarian dynamics.
this study shows that SPARC paucity alleviates superoxide-mediated oxidative stress, apoptosis, and autophagy in diabetogenic hepatocytes
Title: SPARC paucity alleviates superoxide-mediated oxidative stress, apoptosis, and autophagy in diabetogenic hepatocytes.
Our in vitro and ex vivo data show osteonectin expression during the calcification process and suggest its potential role as procalcifying factor
Title: Osteonectin (SPARC) Expression in Vascular Calcification: In Vitro and Ex Vivo Studies.
opposite expression of SPARC in the diabetic liver and pancreas may be related to inflammation and immune cell infiltration, degrees of apoptosis and fibrosis, cytoprotective machinery, and cellular insulin levels
Title: Opposite Expression of SPARC between the Liver and Pancreas in Streptozotocin-Induced Diabetic Rats.
SPARC triggers a cell-autonomous program of synapse elimination in cholinergic neurons that likely occurs when protein production peaks during normal development.
Title: SPARC triggers a cell-autonomous program of synapse elimination.
SPARC is involved in obesity-induced adipose insulin resistance and may serve as a potential target in the treatment of obesity and obesity-related insulin resistance.
Title: SPARC is over-expressed in adipose tissues of diet-induced obese rats and causes insulin resistance in 3T3-L1 adipocytes.
These results provide insights into age-related SPARC resistance in skeletal muscle progenitor cells, which may lead to sarcopenia.
Title: Secreted protein acidic and rich in cysteine internalization and its age-related alterations in skeletal muscle progenitor cells.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94599 (e-PCR)
- UniSTS:119847

PMC151926P2 (e-PCR)
- UniSTS:271193

RH140308 (e-PCR)
- UniSTS:222385

RH128632 (e-PCR)
- UniSTS:211940

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in inner ear development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lung development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in ossification	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	EXP Inferred from Experiment more info	PubMed
involved_in regulation of synapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cytokine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gravity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in semicircular canal morphogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
NOT located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
NOT located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	ISO Inferred from Sequence Orthology more info
NOT located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule	ISO Inferred from Sequence Orthology more info
located_in platelet alpha granule membrane	IEA Inferred from Electronic Annotation more info
located_in platelet alpha granule membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SPARC

Names: BM-40; ON; Secreted acidic cystein-rich glycoprotein (osteonectin); basement-membrane protein 40; osteonectin; secreted acidic cysteine rich glycoprotein; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012656.2 → NP_036788.1 SPARC precursor

See identical proteins and their annotated locations for NP_036788.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O08953, P16975, Q6GSZ4

UniProtKB/TrEMBL

A0A8I6ALJ7, A6HEL9

Related

ENSRNOP00000017486.5, ENSRNOT00000017486.9

Conserved Domains (2) summary

cd01328
Location:69 → 150

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

cd16235
Location:153 → 292

EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)