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    fas fatty acid synthase [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 887704, updated on 6-Jun-2024

    Summary

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    Gene symbol
    fas
    Gene description
    fatty acid synthase
    Locus tag
    Rv2524c
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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    Genomic context

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    Sequence:
    NC_000962.3 (2840123..2849332, complement)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene peroxiredoxin Neighboring gene holo-ACP synthase Neighboring gene hypothetical protein Neighboring gene antitoxin VapB17 Neighboring gene ribonuclease VapC17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation. Molle V, et al. J Biol Chem, 2006 Oct 6. PMID 16873379
    2. Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex. Ciccarelli L, et al. Structure, 2013 Jul 2. PMID 23746808
    3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
    4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
    5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The barrel-like structure of Mycobacterium tuberculosis FAS is not just a static scaffold for the catalytic domains, but may play an active role in coordinating fatty acid synthesis.
      Title: Structure and conformational variability of the mycobacterium tuberculosis fatty acid synthase multienzyme complex.
    2. Ser/Thr protein kinase substrates are identified in M. tuberculosis that form part of the type II fatty acid synthase system involved in mycolic acid biosynthesis.
      Title: The condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    fatty acid synthase
    NP_217040.1
    • Fas (fatty acid synthetase)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      2840123..2849332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_217040.1 fatty acid synthase [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_217040.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAD2IPZ5
      Conserved Domains (5) summary
      COG0304
      Location:2600 → 2992
      FabB; 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      COG0331
      Location:1329 → 1722
      FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
      COG4981
      Location:384 → 1090
      COG4981; Enoyl reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
      COG4982
      Location:1743 → 2585
      FabG2; 3-oxoacyl-ACP reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
      cd03447
      Location:1211 → 1330
      FAS_MaoC; the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).
    Nucleotide Protein
    Heading Accession and Version

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