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    SLC35B3 solute carrier family 35 member B3 [ Homo sapiens (human) ]

    Gene ID: 51000, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SLC35B3provided by HGNC
    Official Full Name
    solute carrier family 35 member B3provided by HGNC
    Primary source
    HGNC:HGNC:21601
    See related
    Ensembl:ENSG00000124786 MIM:610845; AllianceGenome:HGNC:21601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI-19; PAPST2; C6orf196
    Summary
    This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in colon (RPKM 11.6), thyroid (RPKM 9.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC35B3 in Genome Data Viewer
    Location:
    6p24.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (8411435..8435567, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (8280719..8304851, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (8411668..8435800, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374910 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:8180101-8180646 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:8230067-8230588 Neighboring gene uncharacterized LOC105374911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96039 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:8383593-8384467 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:8387849-8389048 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96052 Neighboring gene MPRA-validated peak5649 silencer Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96058 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96067 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96069 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96073 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96077 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23962 Neighboring gene uncharacterized LOC100506207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:8435518-8436059 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96121 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96126 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96137 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96153 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96161 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96186 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96299 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96383 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96450 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96469 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96472 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:8619731-8620403 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:8627414-8628613 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96605 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96748 Neighboring gene hepatocellular carcinoma up-regulated long non-coding RNA Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_96779 Neighboring gene uncharacterized LOC112267952

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2. Kamiyama S, et al. J Biol Chem, 2006 Apr 21. PMID 16492677
    2. Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. Goren A, et al. Mol Cell, 2006 Jun 23. PMID 16793546
    3. [Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3]. Li D, et al. Zhonghua Yi Xue Za Zhi, 2010 Nov 30. PMID 21211351
    4. Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. Kamiyama S, et al. Glycobiology, 2011 Feb. PMID 20978009
    5. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The specifically up-regulated non-coding gene HULC in HepG2 cell line has some effects on the expression of its neighboring gene SLC35B3.
      Title: [Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3].
    2. PAPS transporters play a role in the proliferation of colorectal carcinoma cells themselves and take part in a desmoplastic reaction to support cancer growth by controlling their sulfation status.
      Title: Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma.
    3. PAPST2 is a PAPS transporter gene involved in the synthesis of sulfated glycoconjugates in the colon
      Title: Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		  
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phospho-5'-adenylyl sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5'-adenylyl sulfate transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine 3'-phospho 5'-phosphosulfate transporter 2
    Names
    3' phosphoadenosine 5' phosphosulfate transporter 2
    PAPS transporter 2
    solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142540.2 → NP_001136012.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AL355815, BC006973, BX647208, DC357624
      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
      UniProtKB/TrEMBL
      B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:80 → 371
      UAA; UAA transporter family

    2. NM_001142541.3 → NP_001136013.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_001136013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK313522, AL355815, BC006973, BX538271, DB188586, DB576665
      Consensus CDS
      CCDS4508.1
      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
      UniProtKB/TrEMBL
      B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:80 → 371
      UAA; UAA transporter family

    3. NM_001370476.2 → NP_001357405.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL355815
      Consensus CDS
      CCDS4508.1
      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
      UniProtKB/TrEMBL
      B2R8V5
      Related
      ENSP00000496368.1, ENST00000644923.2
      Conserved Domains (1) summary
      pfam08449
      Location:80 → 371
      UAA; UAA transporter family

    4. NM_001370477.1 → NP_001357406.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL355815
      UniProtKB/TrEMBL
      B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 308
      UAA; UAA transporter family

    5. NM_001370478.2 → NP_001357407.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 3.
      Source sequence(s)
      AL355815
      Consensus CDS
      CCDS93854.1
      UniProtKB/TrEMBL
      A0A024QZW4, B2R8V5
      Related
      ENSP00000498054.1, ENST00000648987.1
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 339
      UAA; UAA transporter family

    6. NM_001370479.2 → NP_001357408.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 3.
      Source sequence(s)
      AL355815
      Consensus CDS
      CCDS93854.1
      UniProtKB/TrEMBL
      A0A024QZW4, B2R8V5
      Related
      ENSP00000518269.1, ENST00000710437.1
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 339
      UAA; UAA transporter family

    7. NM_015948.5 → NP_057032.2  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform 1

      See identical proteins and their annotated locations for NP_057032.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK303940, AL355815, BC006973, BX538271, DB188586, DB576665
      Consensus CDS
      CCDS4508.1
      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
      UniProtKB/TrEMBL
      B2R8V5
      Related
      ENSP00000368981.4, ENST00000379660.4
      Conserved Domains (1) summary
      pfam08449
      Location:80 → 371
      UAA; UAA transporter family

    RNA

    1. NR_109913.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' region and contains an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK303940, AK313522, AL355815, BX538271, DB188586, DB576665

    2. NR_109914.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate splice site in the 5' terminal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL355815, BX647208, DB188586, DB576665

    3. NR_163441.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355815
      Related
      ENST00000648867.1

    4. NR_163442.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL355815

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      8411435..8435567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010912.3 → XP_016866401.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

      UniProtKB/TrEMBL
      B2R8V5

    2. XM_011514648.2 → XP_011512950.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      See identical proteins and their annotated locations for XP_011512950.1

      UniProtKB/TrEMBL
      A0A024QZW4, B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:48 → 339
      UAA; UAA transporter family

    3. XM_047418848.1 → XP_047274804.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X9

    4. XM_047418842.1 → XP_047274798.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    5. XM_047418844.1 → XP_047274800.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    6. XM_006715103.4 → XP_006715166.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

      UniProtKB/TrEMBL
      B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:82 → 342
      UAA; UAA transporter family

    7. XM_047418845.1 → XP_047274801.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    8. XM_047418841.1 → XP_047274797.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

    9. XM_047418840.1 → XP_047274796.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1

    10. XM_017010913.2 → XP_016866402.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

      UniProtKB/TrEMBL
      B2R8V5

    11. XM_017010910.2 → XP_016866399.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
      UniProtKB/TrEMBL
      B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:80 → 371
      UAA; UAA transporter family

    12. XM_017010911.2 → XP_016866400.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308
      UniProtKB/TrEMBL
      B2R8V5
      Conserved Domains (1) summary
      pfam08449
      Location:80 → 371
      UAA; UAA transporter family

    13. XM_047418843.1 → XP_047274799.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    14. XM_047418846.1 → XP_047274802.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X7

    15. XM_047418847.1 → XP_047274803.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X8

    16. XM_047418849.1 → XP_047274805.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X10

    RNA

    1. XR_007059268.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      8280719..8304851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355541.1 → XP_054211516.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    2. XM_054355544.1 → XP_054211519.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    3. XM_054355543.1 → XP_054211518.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    4. XM_054355549.1 → XP_054211524.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X9

    5. XM_054355542.1 → XP_054211517.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    6. XM_054355546.1 → XP_054211521.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    7. XM_054355539.1 → XP_054211514.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X4

    8. XM_054355545.1 → XP_054211520.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X6

      UniProtKB/TrEMBL
      A0A024QZW4

    9. XM_054355537.1 → XP_054211512.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X2

    10. XM_054355536.1 → XP_054211511.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1

    11. XM_054355540.1 → XP_054211515.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X5

    12. XM_054355538.1 → XP_054211513.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      A6NKX9, Q1XH11, Q6MZJ0, Q7Z662, Q9H1N7, Q9Y308

    13. XM_054355547.1 → XP_054211522.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X7

    14. XM_054355548.1 → XP_054211523.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X8

    15. XM_054355550.1 → XP_054211525.1  adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X10

    RNA

    1. XR_008487337.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H1N7.1 GenPept UniProtKB/Swiss-Prot:Q9H1N7

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