U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CADM4 cell adhesion molecule 4 [ Homo sapiens (human) ]

    Gene ID: 199731, updated on 17-Jun-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CADM4provided by HGNC
    Official Full Name
    cell adhesion molecule 4provided by HGNC
    Primary source
    HGNC:HGNC:30825
    See related
    Ensembl:ENSG00000105767 MIM:609744; AllianceGenome:HGNC:30825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NECL4; TSLL2; IGSF4C; Necl-4; synCAM4
    Summary
    Enables vascular endothelial growth factor receptor 2 binding activity. Involved in several processes, including negative regulation of protein phosphorylation; regulation of Rac protein signal transduction; and regulation of wound healing. Located in cell leading edge and cell-cell contact zone. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 59.7), kidney (RPKM 14.7) and 8 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CADM4 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43622368..43641984, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46444027..46463643, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44126520..44144002, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14730 Neighboring gene zinc finger protein 576 Neighboring gene zinc finger protein 428 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44123140-44123790 Neighboring gene uncharacterized LOC105372411 Neighboring gene serine/arginine repetitive matrix 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44127716-44128216 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:44128217-44128717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10725 Neighboring gene plasminogen activator, urokinase receptor Neighboring gene RNA, 7SL, cytoplasmic 368, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10726 Neighboring gene uncharacterized LOC124904724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14732 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:44183469-44183968

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer. Luo F, et al. Int J Biochem Cell Biol, 2020 Jun. PMID 32325280
    2. Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast. Jang SM, et al. J Clin Pathol, 2013 Aug. PMID 23559354
    3. Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. Nagata M, et al. Int J Cancer, 2012 Mar 15. PMID 21544807
    4. Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4. Williams YN, et al. Oncogene, 2006 Mar 9. PMID 16261159
    5. Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2. Yamana S, et al. Biochem Biophys Res Commun, 2017 Aug 19. PMID 28601637

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
      Title: Cell adhesion molecule 4 suppresses cell growth and metastasis by inhibiting the Akt signaling pathway in non-small cell lung cancer.
    2. There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 in gastric or colon adenocarcinomas
      Title: Necl 4 and RNase 5 Are Important Biomarkers for Gastric and Colon Adenocarcinomas.
    3. Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma.
      Title: Neuroblastoma cells undergo transcriptomic alterations upon dissemination into the bone marrow and subsequent tumor progression.
    4. The results suggest that Necl-4 enhances VEGF-induced activation of PLCgamma-c-Raf-MEK-ERK pathway without affecting the phosphorylation and internalization of VEGFR2.
      Title: Necl-4 enhances the PLCγ-c-Raf-MEK-ERK pathway without affecting internalization of VEGFR2.
    5. Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13
      Title: The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
    6. results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2/ErbB3 signaling and hemidesmosome disassembly
      Title: Interaction of Necl-4/CADM4 with ErbB3 and integrin α6 β4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
    7. Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters.
      Title: Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast.
    8. Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane.
      Title: Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy.
    9. CADM4, as well as 4.1B is expressed specifically in human proximal tubules.
      Title: Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma.
    10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide pleiotropy of osteoporosis-related phenotypes: the Framingham Study.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vascular endothelial growth factor receptor 1 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vascular endothelial growth factor receptor 2 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables vascular endothelial growth factor receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of Rac protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rac protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell-cell contact zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cell adhesion molecule 4
    Names
    TSLC1-like 2
    TSLC1-like protein 2
    immunoglobulin superfamily member 4C
    nectin-like 4
    nectin-like protein 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145296.2 → NP_660339.1  cell adhesion molecule 4 precursor

      See identical proteins and their annotated locations for NP_660339.1

      Status: VALIDATED

      Source sequence(s)
      AC005525, AF363368
      Consensus CDS
      CCDS12627.1
      UniProtKB/Swiss-Prot
      B2R7L5, Q8NFZ8, Q9Y4A4
      Related
      ENSP00000222374.1, ENST00000222374.3
      Conserved Domains (5) summary
      smart00294
      Location:344 → 362
      4.1m; putative band 4.1 homologues' binding motif
      pfam13927
      Location:224 → 295
      Ig_3; Immunoglobulin domain
      cd00096
      Location:30 → 36
      Ig; Ig strand A' [structural motif]
      cd05885
      Location:121 → 220
      IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains
      cl11960
      Location:29 → 120
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43622368..43641984 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017026452.1 → XP_016881941.1  cell adhesion molecule 4 isoform X1

      Conserved Domains (5) summary
      smart00294
      Location:325 → 343
      4.1m; putative band 4.1 homologues' binding motif
      cd05885
      Location:121 → 201
      Ig2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4, also known as cell adhesion molecule 4 (CADM4))
      smart00408
      Location:218 → 279
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:212 → 289
      IG_like; Immunoglobulin like
      cl11960
      Location:10 → 101
      Ig; Immunoglobulin domain

    2. XM_005258620.3 → XP_005258677.1  cell adhesion molecule 4 isoform X2

      Conserved Domains (4) summary
      pfam13927
      Location:224 → 295
      Ig_3; Immunoglobulin domain
      cd00096
      Location:30 → 36
      Ig; Ig strand A' [structural motif]
      cd05885
      Location:121 → 220
      IgI_2_Necl-4; Second immunoglobulin (Ig)-like domain of nectin-like molecule-4 (Necl-4); member of the I-set of Ig superfamily domains
      cl11960
      Location:29 → 120
      Ig; Immunoglobulin domain

    3. XM_047438387.1 → XP_047294343.1  cell adhesion molecule 4 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46444027..46463643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320161.1 → XP_054176136.1  cell adhesion molecule 4 isoform X1

    2. XM_054320162.1 → XP_054176137.1  cell adhesion molecule 4 isoform X2

    3. XM_054320163.1 → XP_054176138.1  cell adhesion molecule 4 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NFZ8.1 GenPept UniProtKB/Swiss-Prot:Q8NFZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools