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    ZDHHC20 zinc finger DHHC-type palmitoyltransferase 20 [ Homo sapiens (human) ]

    Gene ID: 253832, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZDHHC20provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 20provided by HGNC
    Primary source
    HGNC:HGNC:20749
    See related
    Ensembl:ENSG00000180776 MIM:617972; AllianceGenome:HGNC:20749
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DHHC20; DHHC-20; 4933421L13Rik
    Summary
    Enables protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in peptidyl-L-cysteine S-palmitoylation and positive regulation by host of viral process. Located in Golgi membrane and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in stomach (RPKM 21.2), urinary bladder (RPKM 18.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC20 in Genome Data Viewer
    Location:
    13q12.11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (21372571..21459303, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (20566901..20653645, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21946710..22033442, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene mitochondrial intermediate peptidase pseudogene 3 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 52 Neighboring gene nitric oxide synthase-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21951083-21951599 Neighboring gene RNA, 5S ribosomal pseudogene 25 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:21983937-21984794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5161 Neighboring gene uncharacterized LOC124903131 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5162 Neighboring gene H2B histone pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The palmitoyltransferase ZDHHC20 enhances interferon-induced transmembrane protein 3 (IFITM3) palmitoylation and antiviral activity. McMichael TM, et al. J Biol Chem, 2017 Dec 29. PMID 29079573, Free PMC Article
    2. DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis. Stix R, et al. Biophys J, 2020 Feb 25. PMID 31858978, Free PMC Article
    3. Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase. Lee CJ, et al. Proc Natl Acad Sci U S A, 2022 Feb 15. PMID 35140179, Free PMC Article
    4. DHHC20: a human palmitoyl acyltransferase that causes cellular transformation. Draper JM, et al. Mol Membr Biol, 2010 Apr. PMID 20334580, Free PMC Article
    5. S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca(2+) signaling by Jurkat T cell receptors at the immune synapse. Carreras-Sureda A, et al. Elife, 2021 Dec 16. PMID 34913437, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
      Title: Palmitoyl transferase ZDHHC20 promotes pancreatic cancer metastasis.
    2. ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.
      Title: ZDHHC20-mediated S-palmitoylation of YTHDF3 stabilizes MYC mRNA to promote pancreatic cancer progression.
    3. Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase.
      Title: Bivalent recognition of fatty acyl-CoA by a human integral membrane palmitoyltransferase.
    4. Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis.
      Title: Regulation of EGFR signalling by palmitoylation and its role in tumorigenesis.
    5. S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca(2+) signaling by Jurkat T cell receptors at the immune synapse.
      Title: S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca(2+) signaling by Jurkat T cell receptors at the immune synapse.
    6. DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis.
      Title: DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis.
    7. crystal structure determined; active site resides at the membrane-cytosol interface; acyl chain binds in a cavity formed by the transmembrane domain; propose a mechanism for acyl chain-length selectivity in DHHC enzymes on the basis of cavity mutants with preferences for shorter and longer acyl chains
      Title: Fatty acyl recognition and transfer by an integral membrane S-acyltransferase.
    8. Targeting of a peripheral modulator of EGFR signaling, DHHC20, causes a loss of signal regulation and susceptibility to EGFR inhibitor-induced cell death.
      Title: Inhibition of DHHC20-Mediated EGFR Palmitoylation Creates a Dependence on EGFR Signaling.
    9. DHHC20 is a human N-terminal-myristoyl-directed palmitoyl acyltransferase involved in cellular transformation, that may play a role in cancer.
      Title: DHHC20: a human palmitoyl acyltransferase that causes cellular transformation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger, DHHC-type containing 20 (ZDHHC20) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25952, MGC126005

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-myristoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-cysteine S-stearoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation by host of viral process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation by host of viral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC20
    Names
    DHHC domain-containing cysteine-rich protein 20
    acyltransferase ZDHHC20
    probable palmitoyltransferase ZDHHC20
    zinc finger DHHC domain-containing protein 20
    zinc finger DHHC-type containing 20
    NP_001273567.1
    NP_001316988.1
    NP_694983.2
    XP_006719859.1
    XP_006719860.1
    XP_011533332.1
    XP_016876014.1
    XP_047286198.1
    XP_047286199.1
    XP_047286200.1
    XP_047286201.1
    XP_047286202.1
    XP_047286203.1
    XP_047286204.1
    XP_054230365.1
    XP_054230366.1
    XP_054230367.1
    XP_054230368.1
    XP_054230369.1
    XP_054230370.1
    XP_054230371.1
    XP_054230372.1
    XP_054230373.1
    XP_054230374.1
    XP_054230375.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286638.2 → NP_001273567.1  palmitoyltransferase ZDHHC20 isoform 2

      See identical proteins and their annotated locations for NP_001273567.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK299354, AL136219, BU685378
      Consensus CDS
      CCDS73551.1
      UniProtKB/TrEMBL
      B4DRN8
      Related
      ENSP00000443236.1, ENST00000542645.5
      Conserved Domains (1) summary
      cl19890
      Location:52 → 238
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_001330059.2 → NP_001316988.1  palmitoyltransferase ZDHHC20 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site, contains an alternate exon in the 3' coding region and differs in its 3' UTR, compared to variant 1. The encoded isoform (3) is longer and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB040396, AL136219, BC067898, BU685378, CR737535, DR003340
      Consensus CDS
      CCDS81758.1
      UniProtKB/Swiss-Prot
      A8MTV9, C9JG20, I6L9D4, Q2TB82, Q5W0Z9, Q6NVU8
      UniProtKB/TrEMBL
      B4DIW0
      Related
      ENSP00000383433.3, ENST00000400590.8
      Conserved Domains (1) summary
      cl19890
      Location:16 → 301
      zf-DHHC; DHHC palmitoyltransferase

    3. NM_153251.4 → NP_694983.2  palmitoyltransferase ZDHHC20 isoform 1

      See identical proteins and their annotated locations for NP_694983.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL136219, BC050367, BG720734, BU685378
      Consensus CDS
      CCDS45017.1
      UniProtKB/TrEMBL
      B4DIW0
      Related
      ENSP00000371905.3, ENST00000382466.7
      Conserved Domains (1) summary
      cl19890
      Location:16 → 301
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. NR_104486.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL136219, BC067898, BU685378

    2. NR_104487.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL136219, BC034944, BC110517, BU685378

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      21372571..21459303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006719796.2 → XP_006719859.1  palmitoyltransferase ZDHHC20 isoform X1

      See identical proteins and their annotated locations for XP_006719859.1

      UniProtKB/TrEMBL
      B4DIW0
      Conserved Domains (1) summary
      cl19890
      Location:16 → 301
      DHHC; DHHC palmitoyltransferase

    2. XM_006719797.2 → XP_006719860.1  palmitoyltransferase ZDHHC20 isoform X2

      See identical proteins and their annotated locations for XP_006719860.1

      UniProtKB/TrEMBL
      B4DIW0
      Conserved Domains (1) summary
      cl19890
      Location:16 → 301
      DHHC; DHHC palmitoyltransferase

    3. XM_047430246.1 → XP_047286202.1  palmitoyltransferase ZDHHC20 isoform X8

    4. XM_047430245.1 → XP_047286201.1  palmitoyltransferase ZDHHC20 isoform X7

    5. XM_047430244.1 → XP_047286200.1  palmitoyltransferase ZDHHC20 isoform X6

      UniProtKB/TrEMBL
      B4DRN8

    6. XM_047430243.1 → XP_047286199.1  palmitoyltransferase ZDHHC20 isoform X4

    7. XM_017020525.2 → XP_016876014.1  palmitoyltransferase ZDHHC20 isoform X5

      Conserved Domains (1) summary
      cl19890
      Location:44 → 230
      DHHC; DHHC palmitoyltransferase

    8. XM_047430247.1 → XP_047286203.1  palmitoyltransferase ZDHHC20 isoform X10

    9. XM_047430248.1 → XP_047286204.1  palmitoyltransferase ZDHHC20 isoform X10

    10. XM_011535030.4 → XP_011533332.1  palmitoyltransferase ZDHHC20 isoform X9

      Conserved Domains (1) summary
      cl19890
      Location:58 → 153
      DHHC; DHHC palmitoyltransferase

    11. XM_047430242.1 → XP_047286198.1  palmitoyltransferase ZDHHC20 isoform X3

      Related
      ENSP00000313583.9, ENST00000320220.13

    RNA

    1. XR_007063672.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      20566901..20653645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374390.1 → XP_054230365.1  palmitoyltransferase ZDHHC20 isoform X1

    2. XM_054374391.1 → XP_054230366.1  palmitoyltransferase ZDHHC20 isoform X2

    3. XM_054374397.1 → XP_054230372.1  palmitoyltransferase ZDHHC20 isoform X8

    4. XM_054374396.1 → XP_054230371.1  palmitoyltransferase ZDHHC20 isoform X7

    5. XM_054374395.1 → XP_054230370.1  palmitoyltransferase ZDHHC20 isoform X6

      UniProtKB/TrEMBL
      B4DRN8

    6. XM_054374393.1 → XP_054230368.1  palmitoyltransferase ZDHHC20 isoform X4

    7. XM_054374394.1 → XP_054230369.1  palmitoyltransferase ZDHHC20 isoform X5

    8. XM_054374399.1 → XP_054230374.1  palmitoyltransferase ZDHHC20 isoform X10

    9. XM_054374400.1 → XP_054230375.1  palmitoyltransferase ZDHHC20 isoform X10

    10. XM_054374398.1 → XP_054230373.1  palmitoyltransferase ZDHHC20 isoform X9

    11. XM_054374392.1 → XP_054230367.1  palmitoyltransferase ZDHHC20 isoform X3

    RNA

    1. XR_008488750.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5W0Z9.1 GenPept UniProtKB/Swiss-Prot:Q5W0Z9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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