TAS2R60 taste 2 receptor member 60 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R60provided by HGNC
Official Full Name: taste 2 receptor member 60provided by HGNC
Primary source: HGNC:HGNC:20639
See related: Ensembl:ENSG00000185899 MIM:613968; AllianceGenome:HGNC:20639
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R56; T2R60
Summary: This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017]
Orthologs: mouse all
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Genomic context

Location:: 7q35

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (143443453..143444409)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (144798817..144799773)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (143140546..143141502)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484188

TAS2R60__5212 (e-PCR)
- UniSTS:464589

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	NAS Non-traceable Author Statement more info	PubMed
NOT enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
NOT involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of bitter taste	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 60

Names: taste receptor type 2 member 56; taste receptor, type 2, member 60

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177437.1 → NP_803186.1 taste receptor type 2 member 60

See identical proteins and their annotated locations for NP_803186.1

Status: REVIEWED

Source sequence(s)

AY114094

Consensus CDS

CCDS5885.1

UniProtKB/Swiss-Prot

A4D2G8, P59551, Q645W8, Q7RTR7

UniProtKB/TrEMBL

Q50KC8

Related

ENSP00000327724.1, ENST00000332690.1

Conserved Domains (1) summary

cd15018
Location:31 → 308

7tm_TAS2R41-like; mammalian taste receptor 2, subtype 41, member of the seven-transmembrane G protein-coupled receptor superfamily