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    C11orf58 chromosome 11 open reading frame 58 [ Homo sapiens (human) ]

    Gene ID: 10944, updated on 6-Oct-2024

    Summary

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    Official Symbol
    C11orf58provided by HGNC
    Official Full Name
    chromosome 11 open reading frame 58provided by HGNC
    Primary source
    HGNC:HGNC:16990
    See related
    Ensembl:ENSG00000110696 MIM:619625; AllianceGenome:HGNC:16990
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMAP; IMAGE145052
    Expression
    Ubiquitous expression in thyroid (RPKM 25.7), endometrium (RPKM 22.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C11orf58 in Genome Data Viewer
    Location:
    11p15.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (16738647..16758340)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (16836026..16855719)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (16760194..16779887)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 6 Neighboring gene MPRA-validated peak1218 silencer Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16628669-16629170 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16629171-16629670 Neighboring gene uncharacterized LOC105376571 Neighboring gene RNA, 7SL, cytoplasmic 188, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16691079-16691580 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16691581-16692082 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16699888-16700416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16700417-16700944 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:16730412-16730912 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:16730913-16731413 Neighboring gene MPRA-validated peak1219 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16800297-16801020 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:16801021-16801743 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16802139-16802833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16802834-16803527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16803848-16804825 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16812092-16812592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16812593-16813093 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:16823697-16824896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:16836605-16837105 Neighboring gene pleckstrin homology domain containing A7 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:16875052-16875264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4481 Neighboring gene VISTA enhancer hs2096 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:16918881-16919566 Neighboring gene RN7SK pseudogene 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:16946213-16946824 Neighboring gene small nucleolar RNA, C/D box 147

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel genes expressed in the chick otocyst during development: identification using differential display of RNA. Gong TW, et al. Int J Dev Neurosci, 1997 Jul. PMID 9263035
    2. Splicing Regulator p54(nrb) /Non-POU Domain-Containing Octamer-Binding Protein Enhances Carcinogenesis Through Oncogenic Isoform Switch of MYC Box-Dependent Interacting Protein 1 in Hepatocellular Carcinoma. Hu Z, et al. Hepatology, 2020 Aug. PMID 31815296
    3. Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding. Huang X, et al. J Biol Chem, 2019 Aug 16. PMID 31248990, Free PMC Article
    4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. Tao WA, et al. Nat Methods, 2005 Aug. PMID 16094384
    5. Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Zhang J, et al. Nat Commun, 2023 Apr 28. PMID 37117180, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117265, DKFZp686N0232

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    small acidic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014267.6 → NP_055082.1  small acidic protein

      See identical proteins and their annotated locations for NP_055082.1

      Status: VALIDATED

      Source sequence(s)
      AC026639
      Consensus CDS
      CCDS7822.1
      UniProtKB/Swiss-Prot
      B2RD28, O00193
      Related
      ENSP00000228136.4, ENST00000228136.9
      Conserved Domains (1) summary
      pfam15477
      Location:27 → 103
      SMAP; Small acidic protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      16738647..16758340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017143.3 → XP_016872632.1  small acidic protein isoform X1

      Conserved Domains (1) summary
      pfam15477
      Location:1 → 59
      SMAP; Small acidic protein family

    2. XM_047426310.1 → XP_047282266.1  small acidic protein isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      16836026..16855719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001142705.1: Suppressed sequence

      Description
      NM_001142705.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O00193.1 GenPept UniProtKB/Swiss-Prot:O00193

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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