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    PSG4 pregnancy specific beta-1-glycoprotein 4 [ Homo sapiens (human) ]

    Gene ID: 5672, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PSG4provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 4provided by HGNC
    Primary source
    HGNC:HGNC:9521
    See related
    Ensembl:ENSG00000243137 MIM:176393; AllianceGenome:HGNC:9521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSG9; PSBG-4; PSBG-9
    Summary
    The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Restricted expression toward placenta (RPKM 137.5) See more
    Orthologs
    all
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    Genomic context

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    See PSG4 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43192702..43205638, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46013303..46026253, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43696854..43709790, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PSG11, PSG2 and PSG5 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 9 pseudogene Neighboring gene pregnancy specific beta-1-glycoprotein 5 Neighboring gene uncharacterized LOC284344 Neighboring gene CEA cell adhesion molecule pseudogene 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:43754009-43754509 Neighboring gene pregnancy specific beta-1-glycoprotein 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. . Biochem Biophys Res Commun, 1990 May 16. PMID 2346490
    2. Pregnancy-specific glycoprotein gene expression and the induction by 5-bromo-2'-deoxyuridine. Pan CJ, et al. Biochemistry, 1994 Jun 14. PMID 8003489
    3. Characterization of cDNA encoding human pregnancy-specific beta 1-glycoprotein from placenta and extraplacental tissues and their comparison with carcinoembryonic antigen. Chan WY, et al. DNA, 1988 Oct. PMID 3180995
    4. Characterization of new members of the pregnancy-specific beta 1-glycoprotein family. Chan WY, et al. Mol Cell Biochem, 1991 Aug 14. PMID 1922019
    5. Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. Barnett TR, et al. Biochemistry, 1990 Nov 6. PMID 2271648

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific beta-1-glycoprotein 4
    Names
    PS-beta-G-4
    PS-beta-G-9
    Pregnancy-specific beta-1-glycoprotein-4
    pregnancy-specific beta-1-glycoprotein 9
    pregnancy-specific glycoprotein 4
    pregnancy-specific glycoprotein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276495.2 → NP_001263424.1  pregnancy-specific beta-1-glycoprotein 4 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005392, AK075149, BC008405
      Consensus CDS
      CCDS62695.1
      UniProtKB/TrEMBL
      B3KQL2
      Related
      ENSP00000387864.2, ENST00000433626.6
      Conserved Domains (3) summary
      cd05740
      Location:148 → 236
      IgI_hCEACAM_2_4_6_like; Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains
      cd05774
      Location:36 → 138
      IgV_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cd20948
      Location:245 → 320
      IgC2_CEACAM5-like; Fifth immunoglobulin (Ig)-like domain of the carcinoembryonic antigen (CEA) related cell adhesion molecule 5 (CEACAM5) and similar domains; member of the C2-set IgSF domains

    2. NM_001316339.2 → NP_001303268.1  pregnancy-specific beta-1-glycoprotein 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005392, BC008405, BC063127, DA837940, DA838139
      UniProtKB/TrEMBL
      M0R0B3
      Related
      ENSP00000471124.1, ENST00000596907.5
      Conserved Domains (3) summary
      smart00410
      Location:217 → 289
      IG_like; Immunoglobulin like
      pfam13895
      Location:213 → 291
      Ig_2; Immunoglobulin domain
      cl11960
      Location:119 → 207
      Ig; Immunoglobulin domain

    3. NM_002780.5 → NP_002771.2  pregnancy-specific beta-1-glycoprotein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_002771.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC005392, BC008405, BC013431
      Consensus CDS
      CCDS46093.1
      UniProtKB/Swiss-Prot
      E7EX79, Q00888, Q13047, Q13048, Q15234, Q15240, Q9UQ76
      UniProtKB/TrEMBL
      Q6P520
      Related
      ENSP00000384770.3, ENST00000405312.8
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:339 → 411
      IG_like; Immunoglobulin like
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cl11960
      Location:241 → 329
      Ig; Immunoglobulin domain

    4. NM_213633.3 → NP_998798.1  pregnancy-specific beta-1-glycoprotein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_998798.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC005392, BC008405, U18469
      Consensus CDS
      CCDS33039.1
      UniProtKB/Swiss-Prot
      Q00888
      UniProtKB/TrEMBL
      Q96QL5
      Related
      ENSP00000244295.8, ENST00000244295.13
      Conserved Domains (4) summary
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246 → 318
      IG_like; Immunoglobulin like
      pfam13895
      Location:242 → 320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43192702..43205638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439105.1 → XP_047295061.1  pregnancy-specific beta-1-glycoprotein 4 isoform X4

    2. XM_047439104.1 → XP_047295060.1  pregnancy-specific beta-1-glycoprotein 4 isoform X3

    3. XM_047439103.1 → XP_047295059.1  pregnancy-specific beta-1-glycoprotein 4 isoform X1

    4. XM_017026997.3 → XP_016882486.1  pregnancy-specific beta-1-glycoprotein 4 isoform X2

      UniProtKB/TrEMBL
      Q6P520

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      46013303..46026253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321489.1 → XP_054177464.1  pregnancy-specific beta-1-glycoprotein 4 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q00888.3 GenPept UniProtKB/Swiss-Prot:Q00888

    Gene LinkOut

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