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    ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 27, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ABL2provided by HGNC
    Official Full Name
    ABL proto-oncogene 2, non-receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:77
    See related
    Ensembl:ENSG00000143322 MIM:164690; AllianceGenome:HGNC:77
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARG; ABLL
    Summary
    This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
    Expression
    Ubiquitous expression in gall bladder (RPKM 5.8), appendix (RPKM 2.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ABL2 in Genome Data Viewer
    Location:
    1q25.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (179099330..179229677, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (178454335..178584699, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (179068465..179198812, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FAM20B glycosaminoglycan xylosylkinase Neighboring gene Sharpr-MPRA regulatory region 11809 Neighboring gene ribosomal protein S26 pseudogene 16 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:179055021-179055521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:179056771-179057672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:179057673-179058574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:179060592-179061092 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:179061093-179061593 Neighboring gene torsin family 3 member A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:179082493-179082994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:179082995-179083494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:179107953-179108459 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:179111778-179112977 Neighboring gene uncharacterized LOC124900432 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene SET pseudogene 10 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 11 Neighboring gene beta-1,3-N-acetylgalactosaminyltransferase 1 (Globoside blood group) pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:179198106-179198862 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:179219631-179219803 Neighboring gene cytochrome c oxidase subunit 5B pseudogene 8 Neighboring gene ribosomal protein L39 pseudogene 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of an ETV6-ABL2 fusion transcript in combination with an ETV6 point mutation in a T-cell acute lymphoblastic leukaemia cell line. Griesinger F, et al. Br J Haematol, 2002 Nov. PMID 12406085
    2. Knockout mutation of p27-p55 operon severely reduces replication of Mycobacterium bovis in a macrophagic cell line and survival in a mouse model of infection. Bianco MV, et al. Virulence, 2011 May-Jun. PMID 21543883
    3. Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo. Gil-Henn H, et al. Oncogene, 2013 May 23. PMID 22777352, Free PMC Article
    4. Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS. Mahadeo KM, et al. Blood, 2010 May 6. PMID 20448119
    5. NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens. Liu G, et al. Proteins, 2010 Apr. PMID 20077570, Free PMC Article

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
      Title: Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
    2. Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization.
      Title: Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization.
    3. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2.
      Title: Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2.
    4. CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis.
      Title: CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis.
    5. Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.
      Title: Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.
    6. microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2.
      Title: microRNA-1296 Inhibits Glioma Cell Growth by Targeting ABL2.
    7. miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
      Title: miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
    8. Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.
      Title: Platelet-derived growth factor receptor beta activates Abl2 via direct binding and phosphorylation.
    9. The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
      Title: The ABL2 kinase regulates an HSF1-dependent transcriptional program required for lung adenocarcinoma brain metastasis.
    10. Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells.
      Title: Arg kinase mediates CXCL12/CXCR4-induced invadopodia formation and invasion of glioma cells.
    Submit: New GeneRIF Correction See all GeneRIFs (39)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ22224, FLJ31718, FLJ41441

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables actin monomer binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables non-membrane spanning protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to retinoic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within exploration behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of T cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of establishment of T cell polarity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein modification process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of autophagy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell adhesion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell motility TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase ABL2
    Names
    Abelson tyrosine-protein kinase 2
    abelson-related gene protein
    c-abl oncogene 2, non-receptor tyrosine kinase
    tyrosine-protein kinase ARG
    v-abl Abelson murine leukemia viral oncogene homolog 2
    NP_001129472.1
    NP_001129473.1
    NP_001161708.1
    NP_001161709.1
    NP_001161710.1
    NP_001161711.1
    NP_005149.4
    NP_009298.1
    XP_005245145.1
    XP_016856524.1
    XP_054191965.1
    XP_054191966.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028242.1 RefSeqGene

      Range
      5008..135355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001136000.3 → NP_001129472.1  tyrosine-protein kinase ABL2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame segment in the 3' coding region, compared to variant b. The resulting isoform (d, also known as 1ALCTS) has a distinct N-terminus and is shorter than isoform b.
      Source sequence(s)
      AL139132, BQ014912, BX538317
      Consensus CDS
      CCDS44282.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000339209.3, ENST00000344730.8
      Conserved Domains (5) summary
      smart00808
      Location:945 → 1064
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154 → 247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96 → 149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266 → 528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:273 → 524
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_001136001.2 → NP_001129473.1  tyrosine-protein kinase ABL2 isoform e

      See identical proteins and their annotated locations for NP_001129473.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (e) lacks an alternate in-frame exon in the 5' coding region, and differs in the 3' coding region and 3' UTR, compared to variant b. The resulting isoform (e) has a distinct C-terminus and is shorter than isoform b.
      Source sequence(s)
      AK311045, AL512326, BC065912
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENST00000668691.1
      Conserved Domains (3) summary
      cd09935
      Location:148 → 241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90 → 143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260 → 522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    3. NM_001168236.2 → NP_001161708.1  tyrosine-protein kinase ABL2 isoform f

      See identical proteins and their annotated locations for NP_001161708.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f) lacks an alternate in-frame exon in the 5' coding region, compared to variant b, resulting in an isoform (f, also known as 1BSCTL) that is shorter than isoform b.
      Source sequence(s)
      AL139132, AL512326, BQ014912, FJ542285
      Consensus CDS
      CCDS53436.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000356595.4, ENST00000367623.8
      Conserved Domains (5) summary
      smart00808
      Location:1042 → 1161
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148 → 241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90 → 143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260 → 522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:267 → 518
      Pkinase_Tyr; Protein tyrosine kinase

    4. NM_001168237.2 → NP_001161709.1  tyrosine-protein kinase ABL2 isoform g

      See identical proteins and their annotated locations for NP_001161709.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g) lacks an alternate in-frame segment in the 3' coding region, compared to variant b, resulting in an isoform (g, also known as 1BLCTS) that is shorter than isoform b.
      Source sequence(s)
      AL139132, AL512326, BQ014912, FJ542284
      Consensus CDS
      CCDS53438.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000424697.1, ENST00000511413.5
      Conserved Domains (5) summary
      smart00808
      Location:960 → 1079
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:288 → 539
      Pkinase_Tyr; Protein tyrosine kinase

    5. NM_001168238.2 → NP_001161710.1  tyrosine-protein kinase ABL2 isoform h

      See identical proteins and their annotated locations for NP_001161710.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (h) lacks an alternate in-frame exon in the 5' coding region and an alternate in-frame segment in the 3' coding region, compared to variant b, resulting in an isoform (h, also known as 1BSCTS) that is shorter than isoform b.
      Source sequence(s)
      AL139132, AL512326, BQ014912, FJ542286
      Consensus CDS
      CCDS53437.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000423413.1, ENST00000507173.5
      Conserved Domains (5) summary
      smart00808
      Location:939 → 1058
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:148 → 241
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:90 → 143
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:260 → 522
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:267 → 518
      Pkinase_Tyr; Protein tyrosine kinase

    6. NM_001168239.2 → NP_001161711.1  tyrosine-protein kinase ABL2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (i) differs in the 5' UTR and 5' coding region, and lacks an alternate in-frame segment in the 3' coding region, compared to variant b. The encoded isoform (i, also known as 1ASCTS) has a distinct N-terminus and is shorter than isoform b.
      Source sequence(s)
      AL139132, BQ014912, BX538317, FJ542283
      Consensus CDS
      CCDS53435.1
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000426831.1, ENST00000504405.5
      Conserved Domains (5) summary
      smart00808
      Location:924 → 1043
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133 → 226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75 → 128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245 → 507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:252 → 503
      Pkinase_Tyr; Protein tyrosine kinase

    7. NM_005158.5 → NP_005149.4  tyrosine-protein kinase ABL2 isoform c

      See identical proteins and their annotated locations for NP_005149.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) differs in the 5' UTR and 5' coding region, compared to variant b, resulting in an isoform (c, also known as 1ALCTL) with a distinct and shorter N-terminus, compared to isoform b.
      Source sequence(s)
      AL139132, AL359179, BC065912, BQ014912, BX538317
      Consensus CDS
      CCDS41441.2
      UniProtKB/Swiss-Prot
      P42684
      Related
      ENSP00000423578.1, ENST00000512653.5
      Conserved Domains (5) summary
      smart00808
      Location:1048 → 1167
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:154 → 247
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:96 → 149
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:266 → 528
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:273 → 524
      Pkinase_Tyr; Protein tyrosine kinase

    8. NM_007314.4 → NP_009298.1  tyrosine-protein kinase ABL2 isoform b

      See identical proteins and their annotated locations for NP_009298.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) represents the longest transcript and encodes the longest isoform (b, also known as 1BLCTL).
      Source sequence(s)
      AL139132, AL512326, BQ014912, M35296
      Consensus CDS
      CCDS30947.1
      UniProtKB/Swiss-Prot
      A0M8X0, B7UEF2, B7UEF3, B7UEF4, B7UEF5, P42684, Q5T0X6, Q5W0C5, Q6NZY6, Q7Z301
      Related
      ENSP00000427562.1, ENST00000502732.6
      Conserved Domains (5) summary
      smart00808
      Location:1063 → 1182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:288 → 539
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      179099330..179229677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001035.2 → XP_016856524.1  tyrosine-protein kinase ABL2 isoform X1

      Conserved Domains (4) summary
      smart00808
      Location:1063 → 1182
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:169 → 262
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:111 → 164
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:281 → 543
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    2. XM_005245088.3 → XP_005245145.1  tyrosine-protein kinase ABL2 isoform X2

      See identical proteins and their annotated locations for XP_005245145.1

      UniProtKB/Swiss-Prot
      P42684
      Conserved Domains (4) summary
      smart00808
      Location:1027 → 1146
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:133 → 226
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd11850
      Location:75 → 128
      SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
      cd05052
      Location:245 → 507
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

    RNA

    1. XR_921765.2 RNA Sequence

    2. XR_007058798.1 RNA Sequence

    3. XR_921764.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      178454335..178584699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335990.1 → XP_054191965.1  tyrosine-protein kinase ABL2 isoform X1

    2. XM_054335991.1 → XP_054191966.1  tyrosine-protein kinase ABL2 isoform X2

    RNA

    1. XR_008485997.1 RNA Sequence

    2. XR_008485995.1 RNA Sequence

    3. XR_008485996.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42684.1 GenPept UniProtKB/Swiss-Prot:P42684

    Gene LinkOut

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