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    PARM1 prostate androgen-regulated mucin-like protein 1 [ Homo sapiens (human) ]

    Gene ID: 25849, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PARM1provided by HGNC
    Official Full Name
    prostate androgen-regulated mucin-like protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24536
    See related
    Ensembl:ENSG00000169116 MIM:617688; AllianceGenome:HGNC:24536
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WSC4; Cipar1; PARM-1; DKFZP564O0823
    Summary
    Located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thyroid (RPKM 83.3), colon (RPKM 61.9) and 21 other tissues See more
    Orthologs
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    Genomic context

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    See PARM1 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (74933116..75050113)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (78273250..78390252)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (75858326..75975323)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377280 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:75811383-75812582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15479 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21615 Neighboring gene PARM1 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr4:75916580-75917081 Neighboring gene NANOG hESC enhancer GRCh37_chr4:75951718-75952258 Neighboring gene uncharacterized LOC107986289 Neighboring gene long intergenic non-protein coding RNA 2562 Neighboring gene Sharpr-MPRA regulatory region 9565 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76052289-76052985 Neighboring gene uncharacterized LOC100506253 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:76106257-76106757

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer. Liu YR, et al. J Cell Biochem, 2019 Oct. PMID 31297877
    2. Characterization and identification of PARM-1 as a new potential oncogene. Charfi C, et al. Mol Cancer, 2013 Jul 31. PMID 23902727, Free PMC Article
    3. Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias. Wittler L, et al. Gene, 2012 Sep 15. PMID 22766399
    4. A novel gene overexpressed in the prostate of castrated rats: hormonal regulation, relationship to apoptosis and to acquired prostatic cell androgen independence. Bruyninx M, et al. Endocrinology, 1999 Oct. PMID 10499539
    5. Prostatic androgen repressed message-1 (PARM-1) may play a role in prostatic cell immortalisation. Cornet AM, et al. Prostate, 2003 Aug 1. PMID 12772192

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer.
      Title: Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer.
    2. Our results strongly suggest the oncogenic potential of PARM-1.
      Title: Characterization and identification of PARM-1 as a new potential oncogene.
    3. PARM1 does not play a major role in the development of epispadias
      Title: Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. Ectopic expression of hPARM-1 in PC3 prostate cancer cells increased colony formation, suggesting a probable role in cell proliferation.
      Title: Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prostate androgen-regulated mucin-like protein 1
    Names
    WSC4, cell wall integrity and stress response component 4 homolog
    castration-induced prostatic apoptosis-related protein 1
    prostatic androgen-regulated mucin-like protein 1
    prostatic androgen-repressed message 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015393.4 → NP_056208.2  prostate androgen-regulated mucin-like protein 1 precursor

      See identical proteins and their annotated locations for NP_056208.2

      Status: VALIDATED

      Source sequence(s)
      AC098825, AC110760, AI767320
      Consensus CDS
      CCDS47077.1
      UniProtKB/Swiss-Prot
      B3KMQ9, Q6UWI2, Q96DV8, Q9Y4S1
      Related
      ENSP00000370224.3, ENST00000307428.7
      Conserved Domains (1) summary
      pfam17061
      Location:15 → 310
      PARM; PARM

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      74933116..75050113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531833.1 → XP_011530135.1  prostate androgen-regulated mucin-like protein 1 isoform X1

      Conserved Domains (1) summary
      pfam17061
      Location:50 → 345
      PARM; PARM

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      78273250..78390252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349619.1 → XP_054205594.1  prostate androgen-regulated mucin-like protein 1 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UWI2.1 GenPept UniProtKB/Swiss-Prot:Q6UWI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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