RASGRP3 RAS guanyl releasing protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RASGRP3provided by HGNC
Official Full Name: RAS guanyl releasing protein 3provided by HGNC
Primary source: HGNC:HGNC:14545
See related: Ensembl:ENSG00000152689 MIM:609531; AllianceGenome:HGNC:14545
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GRP3
Summary: The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017]
Expression: Broad expression in lymph node (RPKM 8.7), appendix (RPKM 6.4) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p22.3

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (33436348..33564731)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (33482495..33610876)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (33661415..33789798)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RasGRP3, a Ras guanyl releasing protein 3 that contributes to malignant proliferation and aggressiveness in human esophageal squamous cell carcinoma
Title: RasGRP3, a Ras guanyl releasing protein 3 that contributes to malignant proliferation and aggressiveness in human esophageal squamous cell carcinoma.
In conclusion, these findings provide a new insight into the upregulation of RasGRP3 involved in Notch pathway activation in the development of esophageal squamous cell carcinoma , especially under nutrient deprivation.
Title: Novel transduction of nutrient stress to Notch pathway by RasGRP3 promotes malignant aggressiveness in human esophageal squamous cell carcinoma.
The marked differences between RasGRP3 and RasGRP1 in membrane interaction necessarily will contribute to their different behavior in cells.
Title: Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.
these data show that RasGRP3 exerts its oncogenic effect in papillary thyroid cancer through Akt-mediated MDM2 activation.
Title: RasGRP3 controls cell proliferation and migration in papillary thyroid cancer by regulating the Akt-MDM2 pathway.
RasGRP3 mediates ERK MAPK pathway activation in GNAQ mutant uveal melanoma.
Title: RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.
Knockdown of RasGRP3 inhibited proliferation in prostate neoplasms.
Title: Upregulation of RASGRP3 expression in prostate cancer correlates with aggressive capabilities and predicts biochemical recurrence after radical prostatectomy.
Ras activator RasGRP3 may have a role in the pathological behavior of breast cancer cells and may constitute a therapeutic target for human breast cancer.
Title: Function of RasGRP3 in the formation and progression of human breast cancer.
The identification of the role of RasGRP3 in melanoma highlights its importance, as a Ras activator, in the phosphoinositide signaling pathway in human melanoma.
Title: RasGRP3, a Ras activator, contributes to signaling and the tumorigenic phenotype in human melanoma.
Significant associations were found for the single nucleotide polymorphism rs13385731 of RasGRP3 with malar rash, discoid rash, and antinuclear antibody in patients with systemic lupus erythematosus
Title: TNIP1, SLC15A4, ETS1, RasGRP3 and IKZF1 are associated with clinical features of systemic lupus erythematosus in a Chinese Han population.
RasGRP3 contributes to the malignant phenotype of prostate cancer cells and may constitute a novel therapeutic target for human prostate cancer.
Title: RasGRP3 contributes to formation and maintenance of the prostate cancer phenotype.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

L17709 (e-PCR)
- UniSTS:42599

D10S16 (e-PCR)
- UniSTS:155756

D1S1423 (e-PCR)
- UniSTS:149619

D1S1425 (e-PCR)
- UniSTS:149621

SHGC-52802 (e-PCR)
- UniSTS:21906

RASGRP3_9408 (e-PCR)
- UniSTS:468638

L18441 (e-PCR)
- UniSTS:71348

D2S1679E (e-PCR)
- UniSTS:150711

D2S1998 (e-PCR)
- UniSTS:69339

SHGC-58804 (e-PCR)
- UniSTS:94450

RH93807 (e-PCR)
- UniSTS:92154

WI-11876 (e-PCR)
- UniSTS:17915

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	NAS Non-traceable Author Statement more info	PubMed
enables diacylglycerol binding	NAS Non-traceable Author Statement more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	TAS Traceable Author Statement more info
involved_in small GTPase-mediated signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of guanyl-nucleotide exchange factor complex	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ras guanyl-releasing protein 3

Names: CalDAG-GEFIII; RAS guanyl releasing protein 3 (calcium and DAG-regulated); calcium and DAG-regulated guanine nucleotide exchange factor III; calcium- and diacylglycerol-regulated guanine nucleotide exchange factor III; guanine nucleotide exchange factor for Rap1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_053077.1 RefSeqGene

Range

45302..133384

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001139488.2 → NP_001132960.1 ras guanyl-releasing protein 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 4-6 all encode the same isoform (1).

Source sequence(s)

AA351079, BC027849, BX647990, DA336406, DA439087

Consensus CDS

CCDS46256.1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Related

ENSP00000384192.3, ENST00000403687.8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
NM_001349975.2 → NP_001336904.1 ras guanyl-releasing protein 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).

Source sequence(s)

AC020594

Consensus CDS

CCDS46256.1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
NM_001349976.2 → NP_001336905.1 ras guanyl-releasing protein 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).

Source sequence(s)

AC020594

Consensus CDS

CCDS46256.1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
NM_001349977.2 → NP_001336906.1 ras guanyl-releasing protein 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (6) represents the longest transcript and differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).

Source sequence(s)

AC020594

Consensus CDS

CCDS46256.1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
NM_001349978.2 → NP_001336907.1 ras guanyl-releasing protein 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).

Source sequence(s)

AC020594

Consensus CDS

CCDS54346.1

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:494 → 543

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam13499
Location:427 → 477

EF-hand_7; EF-hand domain pair
NM_001349979.2 → NP_001336908.1 ras guanyl-releasing protein 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).

Source sequence(s)

AC020594

Consensus CDS

CCDS54346.1

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:494 → 543

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam13499
Location:427 → 477

EF-hand_7; EF-hand domain pair
NM_001349980.2 → NP_001336909.1 ras guanyl-releasing protein 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).

Source sequence(s)

AC020594

Consensus CDS

CCDS54346.1

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:494 → 543

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam13499
Location:427 → 477

EF-hand_7; EF-hand domain pair
NM_001349981.2 → NP_001336910.1 ras guanyl-releasing protein 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (10) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).

Source sequence(s)

AC020594

Consensus CDS

CCDS54346.1

UniProtKB/TrEMBL

A8KAB8

Related

ENSP00000520853.1, ENST00000850562.1

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:494 → 543

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam13499
Location:427 → 477

EF-hand_7; EF-hand domain pair
NM_015376.3 → NP_056191.1 ras guanyl-releasing protein 3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in an isoform (2) which is 1 aa shorter than isoform 1. Variants 3 and 7-10 all encode the same isoform (2).

Source sequence(s)

AA351079, AB020653, BC027849, BX114300, BX647990

Consensus CDS

CCDS54346.1

UniProtKB/TrEMBL

A8KAB8

Related

ENSP00000383917.1, ENST00000407811.5

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

cd00029
Location:494 → 543

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam13499
Location:427 → 477

EF-hand_7; EF-hand domain pair
NM_170672.3 → NP_733772.1 ras guanyl-releasing protein 3 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).

Source sequence(s)

AA351079, AC020594, BC027849, BX647990, DA439087

Consensus CDS

CCDS46256.1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Related

ENSP00000385886.3, ENST00000402538.8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

33436348..33564731

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011532746.4 → XP_011531048.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
XM_011532748.4 → XP_011531050.2 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins
XM_047443877.1 → XP_047299833.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61
XM_047443879.1 → XP_047299835.1 ras guanyl-releasing protein 3 isoform X2
XM_047443878.1 → XP_047299834.1 ras guanyl-releasing protein 3 isoform X2
XM_017003761.3 → XP_016859250.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61

UniProtKB/TrEMBL

A8KAB8

Conserved Domains (4) summary

cd06224
Location:11 → 126

REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

smart00147
Location:148 → 384

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

pfam13499
Location:428 → 478

EF-hand_7; EF-hand domain pair

cd20862
Location:488 → 546

C1_RASGRP3; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 3 (RASGRP3) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

33482495..33610876

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054341297.1 → XP_054197272.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61
XM_054341296.1 → XP_054197271.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61
XM_054341298.1 → XP_054197273.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61
XM_054341300.1 → XP_054197275.1 ras guanyl-releasing protein 3 isoform X2
XM_054341299.1 → XP_054197274.1 ras guanyl-releasing protein 3 isoform X2
XM_054341295.1 → XP_054197270.1 ras guanyl-releasing protein 3 isoform X1

UniProtKB/Swiss-Prot

D6W583, O94931, Q53SD7, Q8IV61