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    PAN5 2-dehydropantoate 2-reductase PAN5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856460, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PAN5
    Official Full Name
    2-dehydropantoate 2-reductase PAN5
    Primary source
    SGD:S000001105
    Locus tag
    YHR063C
    See related
    AllianceGenome:SGD:S000001105; FungiDB:YHR063C; VEuPathDB:YHR063C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable 2-dehydropantoate 2-reductase activity and NADP binding activity. Predicted to be involved in pantothenate biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PAN5 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (224030..225169, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Gic1p Neighboring gene RNA-binding RNA processing protein RPP1 Neighboring gene Ssz1p Neighboring gene RNA-dependent ATPase RRP3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae is capable of de Novo pantothenic acid biosynthesis involving a novel pathway of beta-alanine production from spermine. White WH, et al. J Biol Chem, 2001 Apr 6. PMID 11154694
    2. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Huang D, et al. Mol Cell Biol, 2002 Jul. PMID 12077337, Free PMC Article
    3. 14-3-3 Protein Bmh1 triggers short-range compaction of mitotic chromosomes by recruiting sirtuin deacetylase Hst2. Jain N, et al. J Biol Chem, 2021 Jan-Jun. PMID 33187982, Free PMC Article
    4. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Strome ED, et al. Genetics, 2008 Mar. PMID 18245329, Free PMC Article
    5. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2-dehydropantoate 2-reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-dehydropantoate 2-reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-dehydropantoate 2-reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in pantothenate biosynthetic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in pantothenate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    2-dehydropantoate 2-reductase PAN5
    NP_011930.1
    • 2-dehydropantoate 2-reductase; part of the pantothenic acid pathway, structurally homologous to E. coli panE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      224030..225169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179193.1 → NP_011930.1  TPA: 2-dehydropantoate 2-reductase PAN5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011930.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL12, P38787
      UniProtKB/TrEMBL
      A6ZSW9, B3LSI2, C7GTX0, G2WFD5, N1P9D3
      Conserved Domains (1) summary
      TIGR00745
      Location:16 → 369
      apbA_panE; 2-dehydropantoate 2-reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38787.1

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