ERG4 delta(24(24(1)))-sterol reductase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ERG4
Official Full Name: delta(24(24(1)))-sterol reductase
Primary source: SGD:S000002980
Locus tag: YGL012W
See related: AllianceGenome:SGD:S000002980; FungiDB:YGL012W; VEuPathDB:YGL012W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables delta24(24-1) sterol reductase activity and delta24-sterol reductase activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum. Is active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ERG4 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (472855..474276)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables delta24(24-1) sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta24(24-1) sterol reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables delta24(24-1) sterol reductase activity	IEA Inferred from Electronic Annotation more info
enables delta24-sterol reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ergosterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ergosterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: delta(24(24(1)))-sterol reductase

NP_011503.1

EC 1.3.1.71

C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

472855..474276

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180877.1 → NP_011503.1 TPA: delta(24(24(1)))-sterol reductase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011503.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VUC5, E9P929, P25340

UniProtKB/TrEMBL

A6ZUY1, B3LIM7, C7GK61, G2WE81, N1P5L7

Conserved Domains (1) summary

pfam01222
Location:34 → 473

ERG4_ERG24; Ergosterol biosynthesis ERG4/ERG24 family