RPN9 proteasome regulatory particle lid subunit RPN9 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPN9
Official Full Name: proteasome regulatory particle lid subunit RPN9
Primary source: SGD:S000002835
Locus tag: YDR427W
See related: AllianceGenome:SGD:S000002835; FungiDB:YDR427W; VEuPathDB:YDR427W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: NAS7
Summary: Enables structural molecule activity. Involved in proteasome assembly and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleus; and proteasome storage granule. Part of proteasome regulatory particle, lid subcomplex. Orthologous to human PSMD13 (proteasome 26S subunit, non-ATPase 13). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPN9 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (1322205..1323386)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rpn10, but not ubiquitylated-Rpn10, binds Rpn9 in vitro: ubiquitylation functions to dissociate modified ubiquitin receptors from their targets, a function that promotes cyclic activity of ubiquitin receptors
Title: Structure of ubiquitylated-Rpn10 provides insight into its autoregulation mechanism.
Rpn9 interacts with Rpn10 and Rpn5 via its N-terminal alpha-solenoid and C-terminal proteasome-COP9/CSN-initiation factor (PCI) domains, respectively.
Title: Solution structure of yeast Rpn9: insights into proteasome lid assembly.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural molecule activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome regulatory particle, lid subcomplex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IEA Inferred from Electronic Annotation more info
located_in proteasome storage granule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome regulatory particle lid subunit RPN9

NP_010715.3

Non-ATPase regulatory subunit of the 26S proteasome; similar to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

1322205..1323386

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180735.3 → NP_010715.3 TPA: proteasome regulatory particle lid subunit RPN9 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010715.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VT56, Q04062

UniProtKB/TrEMBL

A6ZZ23, B3LFN0, C7GTN3, C8Z5Y8, G2WBG2, N1P8W6

Conserved Domains (2) summary

pfam01399
Location:249 → 352

PCI; PCI domain

pfam18261
Location:356 → 388

Rpn9_C; Rpn9 C-terminal helix