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    NOP1 rRNA methyltransferase NOP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851548, updated on 28-Oct-2024

    Summary

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    Official Symbol
    NOP1
    Official Full Name
    rRNA methyltransferase NOP1
    Primary source
    SGD:S000002172
    Locus tag
    YDL014W
    See related
    AllianceGenome:SGD:S000002172; FungiDB:YDL014W; VEuPathDB:YDL014W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LOT3
    Summary
    Enables histone H2AQ104 methyltransferase activity and rRNA methyltransferase activity. Involved in box C/D sno(s)RNA 3'-end processing and rRNA methylation. Located in nucleolus. Part of box C/D methylation guide snoRNP complex and small-subunit processome. Orthologous to human FBL (fibrillarin) and FBLL1 (fibrillarin like 1). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See NOP1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (427364..428347)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CDC7 Neighboring gene trans-2-enoyl-CoA reductase (NADPH) TSC13 Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. Henríquez R, et al. J Biol Chem, 1990 Feb 5. PMID 2298745
    2. A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. Schimmang T, et al. EMBO J, 1989 Dec 20. PMID 2686980, Free PMC Article
    3. Temperature-sensitive mutations demonstrate roles for yeast fibrillarin in pre-rRNA processing, pre-rRNA methylation, and ribosome assembly. Tollervey D, et al. Cell, 1993 Feb 12. PMID 8431947
    4. A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. Jansen R, et al. EMBO J, 1993 Jun. PMID 8508778, Free PMC Article
    5. Def1 mediates the degradation of excess nucleolar protein Nop1 in budding yeast. Morshed S, et al. Biochem Biophys Res Commun, 2019 Nov 5. PMID 31506176

    See all (190) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein aggregation and the evolution of stress resistance in clinical yeast.
      Title: Protein aggregation and the evolution of stress resistance in clinical yeast.
    2. High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
      Title: High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain.
    3. Studied and discovered 21 native sites of arginine methylation on five putative Hmt1 substrate proteins (Gar1p, Nop1p, Npl3p, Nsr1p, Rps2p).
      Title: Yeast proteins Gar1p, Nop1p, Npl3p, Nsr1p, and Rps2p are natively methylated and are substrates of the arginine methyltransferase Hmt1p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AQ104 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H2AQ104 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box C/D sno(s)RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box C/D sno(s)RNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA methyltransferase NOP1
    NP_010270.1
    • Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; ortholog of mammalian fibrillarin; inviability of the null mutant is functionally complemented by human FBL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      427364..428347
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180073.1 → NP_010270.1  TPA: rRNA methyltransferase NOP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRX5, P15646, P89890
      UniProtKB/TrEMBL
      A6ZXV4, B3LGS1, C7GW64, C8Z4Q5, G2WCE1, N1P5Y0
      Conserved Domains (1) summary
      PTZ00146
      Location:85 → 320
      PTZ00146; fibrillarin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15646.1

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