UBX3 Ubx3p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UBX3
Official Full Name: Ubx3p
Primary source: SGD:S000002249
Locus tag: YDL091C
See related: AllianceGenome:SGD:S000002249; FungiDB:YDL091C; VEuPathDB:YDL091C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables clathrin binding activity. Involved in clathrin-dependent endocytosis. Located in clathrin-coated vesicle. Part of Dsc E3 ubiquitin ligase complex. Orthologous to several human genes including FAF2 (Fas associated factor family member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

a component of the clathrin-mediated endocytosis machinery
Title: New Regulators of Clathrin-Mediated Endocytosis Identified in Saccharomyces cerevisiae by Systematic Quantitative Fluorescence Microscopy.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Dsc E3 ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

NP_010192.1

Clathrin-coated vesicle component, regulator of endocytosis; copurifies with the DSC ubiquitin ligase complex; UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p; required for efficient clathrin-mediated endocytosis; ortholog of fission yeast Ucp10

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The following sections contain reference sequences that belong to a specific genome build. Explain