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    RPC53 DNA-directed RNA polymerase III subunit C53 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851404, updated on 29-Jun-2024

    Summary

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    Gene symbol
    RPC53
    Gene description
    DNA-directed RNA polymerase III subunit C53
    Primary source
    FungiDB:YDL150W
    Locus tag
    YDL150W
    See related
    SGD:S000002309; AllianceGenome:SGD:S000002309; VEuPathDB:YDL150W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPC4
    Summary
    Contributes to RNA polymerase III activity. Involved in tRNA transcription by RNA polymerase III. Part of RNA polymerase III complex. Orthologous to human POLR3D (RNA polymerase III subunit D). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPC53 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (183343..184611)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene MutS family protein MSH5 Neighboring gene rRNA-processing protein SAS10 Neighboring gene autophagy protein ATG9 Neighboring gene snoRNA-binding rRNA-processing protein NOP14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPC53 encodes a subunit of Saccharomyces cerevisiae RNA polymerase C (III) whose inactivation leads to a predominantly G1 arrest. Mann C, et al. Mol Cell Biol, 1992 Oct. PMID 1406624, Free PMC Article
    2. RNA polymerase III interferes with Ty3 integration. Connolly CM, et al. FEBS Lett, 1997 Apr 1. PMID 9108309
    3. Biochemical and genetic dissection of the Saccharomyces cerevisiae RNA polymerase C53 subunit through the analysis of a mitochondrially mis-sorted mutant construct. Chiannilkulchai N, et al. J Biol Chem, 1992 Nov 15. PMID 1429657
    4. Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element. Arimbasseri AG, et al. Mol Cell, 2015 Jun 18. PMID 25959395, Free PMC Article
    5. Distinguishing core and holoenzyme mechanisms of transcription termination by RNA polymerase III. Arimbasseri AG, et al. Mol Cell Biol, 2013 Apr. PMID 23401852, Free PMC Article

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Date indicate that RNA Polymerase III (RNAP III) subunits C53, C37, and C11 are required for pre-termination complex (PTC) formation.
      Title: Mechanism of Transcription Termination by RNA Polymerase III Utilizes a Non-template Strand Sequence-Specific Signal Element.
    2. C53/C37 subcomplex additionally plays a role in formation of the initiation-ready open promoter complex
      Title: The C53/C37 subcomplex of RNA polymerase III lies near the active site and participates in promoter opening.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase III subunit C53
    NP_010131.1
    • RNA polymerase III subunit C53

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      183343..184611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180210.1 → NP_010131.1  TPA: DNA-directed RNA polymerase III subunit C53 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010131.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRJ8, P25441, Q12073
      UniProtKB/TrEMBL
      A0A8H8UME4, A6ZXH7, N1P600
      Conserved Domains (1) summary
      pfam05132
      Location:301 → 420
      RNA_pol_Rpc4; RNA polymerase III RPC4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25441.2

    Gene LinkOut

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