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    BXI1 Bxi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855411, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BXI1
    Official Full Name
    Bxi1p
    Primary source
    SGD:S000005249
    Locus tag
    YNL305C
    See related
    AllianceGenome:SGD:S000005249; FungiDB:YNL305C; VEuPathDB:YNL305C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YBH3
    Summary
    Involved in apoptotic process; calcium-mediated signaling; and endoplasmic reticulum unfolded protein response. Located in endoplasmic reticulum; fungal-type vacuole; and mitochondrion. Orthologous to several human genes including TMBIM4 (transmembrane BAX inhibitor motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BXI1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (58898..59791, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine/tyrosine protein kinase MCK1 Neighboring gene mitochondrial 37S ribosomal protein YmS18 Neighboring gene Rab family GTPase YPT11 Neighboring gene ribosomal 40S subunit protein S19B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Bax inhibitor, Bxi1p, is an ER-localized protein that links the unfolded protein response and programmed cell death in Saccharomyces cerevisiae. Cebulski J, et al. PLoS One, 2011. PMID 21673967, Free PMC Article
    2. Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast. Chae HJ, et al. Gene, 2003 Dec 24. PMID 14659883
    3. Heterologous expression of anti-apoptotic human 14-3-3β/α enhances iron-mediated programmed cell death in yeast. Eid R, et al. PLoS One, 2017. PMID 28854230, Free PMC Article
    4. Role of CNC1 gene in TDP-43 aggregation-induced oxidative stress-mediated cell death in S. cerevisiae model of ALS. Bharathi V, et al. Biochim Biophys Acta Mol Cell Res, 2021 May. PMID 33647321
    5. The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast. Carmona-Gutierrez D, et al. Cell Cycle, 2013 Jun 1. PMID 23656787, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family.
      Title: Yeast Bxi1/Ybh3 mediates conserved mitophagy and apoptosis in yeast and mammalian cells: convergence in Bcl-2 family.
    2. Yeast Bax Inhibitor (Bxi1p/Ybh3p) Is Not Required for the Action of Bcl-2 Family Proteins on Cell Viability.
      Title: Yeast Bax Inhibitor (Bxi1p/Ybh3p) Is Not Required for the Action of Bcl-2 Family Proteins on Cell Viability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bxi1p
    NP_014094.1
    • Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      58898..59791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183143.1 → NP_014094.1  TPA: Bxi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0P0, P48558, Q6B2Q1
      UniProtKB/TrEMBL
      A6ZSH5, B3LPD9, B5VQB5, C7GWQ2, C8ZGL9, G2WLG4, N1NWN4
      Conserved Domains (1) summary
      cd10429
      Location:21 → 294
      GAAP_like; Golgi antiapoptotic protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48558.1

    Gene LinkOut

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