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    ARG2 arginase 2 [ Homo sapiens (human) ]

    Gene ID: 384, updated on 29-Oct-2024

    Summary

    Official Symbol
    ARG2provided by HGNC
    Official Full Name
    arginase 2provided by HGNC
    Primary source
    HGNC:HGNC:664
    See related
    Ensembl:ENSG00000081181 MIM:107830; AllianceGenome:HGNC:664
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in thyroid (RPKM 94.3), prostate (RPKM 64.4) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARG2 in Genome Data Viewer
    Location:
    14q24.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (67619920..67651708)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (61827050..61858841)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68086637..68118425)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene protein kinase C eta pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5860 Neighboring gene uncharacterized LOC124903331 Neighboring gene high mobility group box 1 pseudogene 34 Neighboring gene RNA, 5S ribosomal pseudogene 386 Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 1 Neighboring gene vesicle transport through interaction with t-SNAREs 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr HIV-1 Vpr downregulates the expression of ARG2 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arginase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arginase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables manganese ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in arginine catabolic process to ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of chemokine (C-C motif) ligand 4 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of chemokine (C-C motif) ligand 5 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-13 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-17 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macrophage inflammatory protein 1 alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of type 2 immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nitric oxide biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of cellular senescence IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of interleukin-1 beta production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in striated muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in urea cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    arginase-2, mitochondrial
    Names
    L-arginine amidinohydrolase
    L-arginine ureahydrolase
    arginase II
    arginase, type II
    kidney arginase
    kidney-type arginase
    non-hepatic arginase
    nonhepatic arginase
    type II arginase
    NP_001163.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011964.1 RefSeqGene

      Range
      5059..36847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172.4NP_001163.1  arginase-2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001163.1

      Status: REVIEWED

      Source sequence(s)
      AL135439, BC029050
      Consensus CDS
      CCDS9785.1
      UniProtKB/Swiss-Prot
      B2R690, P78540, Q6FHY8
      Related
      ENSP00000261783.3, ENST00000261783.4
      Conserved Domains (1) summary
      cd09989
      Location:26321
      Arginase; Arginase family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      67619920..67651708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      61827050..61858841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)