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    cap-2 F-actin-capping protein subunit beta [ Caenorhabditis elegans ]

    Gene ID: 174673, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cap-2
    Official Full Name
    F-actin-capping protein subunit beta
    Primary source
    WormBase:WBGene00000293
    Locus tag
    CELE_M106.5
    See related
    AllianceGenome:WB:WBGene00000293
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables actin filament binding activity. Involved in actin cytoskeleton organization and embryonic axis specification. Located in cytoplasm. Part of dynactin complex. Is expressed in hypodermis; pharynx; and tail. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cap-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (10869196..10870827)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Prostaglandin reductase 2 Neighboring gene putative GMP synthase [glutamine-hydrolyzing] Neighboring gene ncRNA Neighboring gene Peptidyl-prolyl cis-trans isomerase 4 Neighboring gene putative coatomer subunit zeta Neighboring gene Origin recognition complex subunit 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The alpha and beta subunits of nematode actin capping protein function in yeast. Waddle JA, et al. Mol Biol Cell, 1993 Sep. PMID 8257793, Free PMC Article
    2. Establishment of initial asymmetry in early Caenorhabditis elegans embryos. Priess JR. Curr Opin Genet Dev, 1994 Aug. PMID 7950325
    3. TAC-1, a regulator of microtubule length in the C. elegans embryo. Le Bot N, et al. Curr Biol, 2003 Sep 2. PMID 12956951
    4. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article
    5. Actin-capping protein regulates actomyosin contractility to maintain germline architecture in C. elegans. Ray S, et al. Development, 2023 Mar 15. PMID 36897576, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of F-actin capping protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynactin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-actin-capping protein subunit beta
    NP_496336.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10869196..10870827
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063935.10 → NP_496336.1  F-actin-capping protein subunit beta [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34686
      Conserved Domains (1) summary
      pfam01115
      Location:11 → 238
      F_actin_cap_B; F-actin capping protein, beta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34686.1

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