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    C17E4.6 Vacuolar protein sorting-associated protein 72 homolog [ Caenorhabditis elegans ]

    Gene ID: 172769, updated on 2-Nov-2024

    Summary

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    Official Symbol
    C17E4.6
    Official Full Name
    Vacuolar protein sorting-associated protein 72 homolog
    Primary source
    WormBase:WBGene00007645
    Locus tag
    CELE_C17E4.6
    See related
    AllianceGenome:WB:WBGene00007645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP-dependent H2AZ histone chaperone activity. Predicted to be involved in transcription initiation-coupled chromatin remodeling. Predicted to be active in nucleus. Orthologous to human VPS72 (vacuolar protein sorting 72 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See C17E4.6 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9422556..9431120)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Methyltransferase domain-containing protein Neighboring gene ABC2_membrane domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Sodium/potassium-transporting ATPase subunit beta-1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
    2. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription initiation-coupled chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vacuolar protein sorting-associated protein 72 homolog
    NP_492505.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9422556..9431120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060104.6 → NP_492505.1  Vacuolar protein sorting-associated protein 72 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93230
      Conserved Domains (3) summary
      pfam05764
      Location:60 → 250
      YL1; YL1 nuclear protein
      pfam08265
      Location:291 → 319
      YL1_C; YL1 nuclear protein C-terminal domain
      cl24021
      Location:5 → 81
      NPR3; Nitrogen Permease regulator of amino acid transport activity 3
    Nucleotide Protein
    Heading Accession and Version

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