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    calm-1 EF-hand domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172774, updated on 2-Nov-2024

    Summary

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    Official Symbol
    calm-1
    Official Full Name
    EF-hand domain-containing protein
    Primary source
    WormBase:WBGene00009260
    Locus tag
    CELE_F30A10.1
    See related
    AllianceGenome:WB:WBGene00009260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity and magnesium ion binding activity. Predicted to be involved in calcium ion homeostasis. Is expressed in body wall musculature; cholinergic neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in Usher syndrome type 1J and autosomal recessive nonsyndromic deafness 48. Orthologous to human CIB2 (calcium and integrin binding family member 2) and CIB3 (calcium and integrin binding family member 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See calm-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (9472642..9474801, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Skp1-related protein Neighboring gene Skp1-related protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Saposin B-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction. Clark S, et al. Proc Natl Acad Sci U S A, 2024 Feb 20. PMID 38354260, Free PMC Article
    2. Structures of the TMC-1 complex illuminate mechanosensory transduction. Jeong H, et al. Nature, 2022 Oct. PMID 36224384, Free PMC Article
    3. Localized sphingolipid signaling at presynaptic terminals is regulated by calcium influx and promotes recruitment of priming factors. Chan JP, et al. J Neurosci, 2012 Dec 5. PMID 23223309, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    EF-hand domain-containing protein
    NP_492514.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9472642..9474801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060113.5 → NP_492514.2  EF-hand domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492514.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93640
      Conserved Domains (2) summary
      COG5126
      Location:32 → 192
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cl08302
      Location:121 → 183
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version

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